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多巴胺D1受体在帕金森脑黑质纹状体的表达

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摘要 目的观察帕金森(PD)病人脑黑质纹状体多巴胺D1受体的表达变化。方法采用免疫放射自显影法观察PD标本(PD组)中黑质纹状体多巴胺D1受体的含量改变,并与非神经系统疾病脑标本(对照组)进行对照研究。结果 PD组多巴胺D1受体标记信号在壳及尾状核比对照组减弱,黑质多巴胺D1受体的标记信号比对照组增强;灰度值分析显示,壳及尾状核的灰度值比对照组分别增加了11.35%和10.52%,而黑质比对照组减了48.89%(P<0.01)。结论多巴胺D1受体在PD人脑标本壳及尾状核的表达降低、黑质表达增加。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第13期1780-1782,共3页 Chinese Journal of Gerontology
基金 河北省科学技术研究与发展指导课题(No.062761385) 河北省自然科学基金(No.C2009001094)
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