吡格列酮配合生活干预对SHR大鼠降压及主动脉壁的保护作用

Pioglitazone combination with life style intervention on blood pressure and the protective effect of aorta in spontaneously hypertensive rats

目的观察胰岛素增敏剂吡格列酮(PIO)配合生活干预对自发性高血压大鼠(SHR)的降压、降糖、调脂作用,以及对主动脉壁的保护作用。方法 SHR大鼠45只,随机分为4组:对照组,PIO组,生活干预组,PIO+生活干预组。药物添加到大鼠饮水中,生活干预为每日减少投食量并游泳6～15min,实验周期为12w。采用尾动脉血压间接测量法定期测血压,并采用生化分析仪测定血糖,血脂。采用光镜方法观察各组大鼠主动脉壁形态学变化情况。结果 PIO有良好的降压、降糖、调脂作用,PIO配合生活干预的降压、降糖、降脂效果更佳,血管保护作用最强。结论 PIO及配合生活干预具有良好的降低SHR大鼠血压及血管保护作用,生活干预可作为纠正IR的方法之一应用到高血压的治疗当中。

Objective To evaluate the effects of insulin sensilizer （ Pioglitazone PIO） combination with life style intervention on blood pressure and glucose and lipid in spontaneously hypertensive rats （ SHRs）, analyze the protective effect of aorta. Methods Forty five SHRs were randomly assigned to SHR control, PIO,life style intervention and PIO combination with life style intervention groups, using re- ducing the rat food and swimming （6 ~ 15 min/d） as life style intervention for 12 w. Results PIO had satisfactory effects on blood pres- sure, glucose and lipid, PIO combine with life style intervention had better protective of aorta. Conclusions PlO combination with life style intervention have satisfactory effects on blood pressure and the aorta,life style intervention could be a good method as rectifying IR on depressurization.