冠心病患者血清缺氧诱导因子-1α与血管内皮生长因子水平的变化

Changes of serum hypoxia-inducible factor-1α and vascular endothelial growth factor in patients with coronary heart disease

目的:研究冠心病(CHD)患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)和低氧诱导因子-1α(hypoxia inducible factor1α,HIF-1α)水平的变化意义。方法:CHD患者79例,分为急性冠脉综合征(ACS)组42例,稳定型心绞痛(SAP)组37例,另选35例作为对照组,所有患者清晨空腹抽血应用ELISA法测定VEGF和HIF-1α水平。结果:ACS组VEGF和HIF-1α水平显著高于SAP组和对照组(P<0.05);SAP组VEGF和HIF-1α水平与对照组比较差异无统计学意义。结论:VEGF和HIF-1α水平升高可能是冠状动脉粥样硬化斑块的不稳定的标志。

AIM： To study the serum level of vascular endothelial growth factor （VEGF） and hypoxia-inducible factor-1α （HIF-1α） in patients with coronary heart disease （CHD） and to discuss their clinical significance. METHODS： Seventy-nine patients with CHD were chosen and divided into two group： acute coronary syndrome （ACS） group （n=42） and stable angina pectoris （SAP） group （n=37）. Thirty-five healthy subjects were chosen as control group. Serum levels of VEGF and HIF-1α from fasting blood were tested in all patients using ELISA. RESULTS： Serum levels of VEGF and HIF-1α in ACS group were higher than those in SAP group and control group （P〈0.05）. No difference was observed in VEGF and HIF-1α between SAP and control group. CONCLUSION： Elevated levels of VEGF and HIF-1α may be signs of atherosclerotic plaque destabilization.