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Wnt信号与骨关节炎 被引量：4

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摘要 骨关节炎（OA）是机械性和生物性因素的作用破坏了关节软骨细胞、细胞外基质和软骨下骨正常合成与降解耦联的结果。经过大量研究,人们发现与OA形成有关的因素包含机械应力、体重、遗传、外伤等。
作者 黄金刚 张晓玲
机构地区 上海交通大学医学院 中国科学院上海生命科学研究院健康科学研究所
出处 《中国运动医学杂志》 CAS CSCD 北大核心 2010年第4期490-493,共4页 Chinese Journal of Sports Medicine
基金 国家自然科学基金(30700402) 上海市重点科技支撑计划项目(08411950400) 上海市科委国际合作项目(08410701800) 上海市骨科内植物重点实验室建设基金(08DZ2230330)
关键词 骨关节炎 WNT信号 机械性 生物性因素
分类号 R684 [医药卫生—骨科学]
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参考文献49

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同被引文献138

  • 1Kuhl M. The Wnt/calcium pathway : Biochemical mediators tools and future requirements. Front Biosci, 2004, 9 : 967-974.
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  • 3Seifert JR, Mlodzik M. Frizzled/PCP signalling : A con- served mechanism regulating cell polarity and directed motility. Nat Rev Genet, 2007, 8 (2) : 126-138.
  • 4Veeman MT, Axelrod JD, Moon RT. A second canon : functions and mechanisms of β-catenin independent Wnt signaling. Dev Cell, 2003, 5 (3) : 367-377.
  • 5Sharma RP, Chopra VL. Effect of the Wingless (wgl) mutation on wing and haltere development in Drosophila melanogaster. Dev Biol, 1976, 48 : 461-465.
  • 6Cabrera CV, Alonso MC, Johnston P, et al . Phenocopies induced with antisense RNA identify the wingless gene. Cell, 1987, 50 (4) : 659-663.
  • 7Nusse R, Theunissen H, Wagenaar E, et al.The Wnt-1 (int-1 ) oncogene promoter and its mechanism of activa- tion by insertion of proviral DNA of the mouse mammary tumor virus. Mol Cell Biol, 1990, 10 (8) : 4170-4179.
  • 8Rijsewijk F, Schuermann M, Wagenaar E, et al. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell, 1987, 50 (4) : 649-657.
  • 9Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell, 1982, 31 : 99-109.
  • 10Cadigan KM, Nusse R. Wnt signaling : a common theme in animal development. Genes Dev, 1997, 11 :3286-3305.

引证文献4

二级引证文献16

中国运动医学杂志
2010年 第4期

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