血必净注射液对重度急性有机磷农药中毒患者炎症介质的影响

Effect of Xuebijing Injection on Systemic Inflammatory Response Syndrome in Patients of Severe Acute Organophosphorus Poisoning

目的:探讨血必净注射液对重度急性有机磷农药中毒(AOPP)患者全身炎性反应综合征(SIRS)的保护作用及其机制。方法:将45例重度AOPP患者随机分成血必净治疗组(23例)和常规治疗组(19例),血必净治疗组在正规治疗的基础上加用血必净注射液,对比观察2组治疗前及治疗后1、3、5d的体温(T)、心率(HR)、呼吸频率(RR)、白细胞计数(WBC)、C反应蛋白(CRP)、血浆肿瘤坏死因子(TNF-α)、白细胞介素(IL)-6及IL-8。结果:治疗后3d、5d,与常规治疗组比较,血必净治疗组患者T、HR、RR、WBC以及CRP明显改善(P<0.05),TNF-α、IL-6、IL-8明显降低(P<0.05或P<0.01)。结论:血必净能有效抑制重度AOPP患者炎症反应过程,明显改善SIRS的症状,可能对AOPP患者的治疗起着重要的协同作用。

Objective：To investigate the protective effect of Xuebijing injection on the systemic inflammatory response syndrome（SIRS） in patients of severe acute organophosphorus poisoning（AOPP） and the mechanisms thereof.Methods：Fortyfive patients with severe acute organophosphorus poisoning were randomly divided into two groups,the group treated with Xuebijing injection（Xuebijing group,23 patients）,and the routine treatment group（control group,19 patients）.The patients were treated with Xuebijing besides the routine treatment in Xuebijing group.The temperature（T）,heart rate（HR）,respiratory rate（RR）,white blood cells（WBC）,C-reactive protein（CRP）,tumor necrosis factor（TNF-α）,interleukin-6（IL-6）,and interleukin8（IL-8） were compared in patients before treatment and after 1,3 and 5 days treatment.Results：The temperature,HR,RR,WBC and CRP were significantly improved（P〈 0.05）,the values of TNF-α,IL-6 and IL-8 were significantly reduced（P〈 0.05 or P 〈0.01） after 3 and 5-day treatment in patients of Xuebijing group compared with those of control group.Conclusion：Xuebijing injection can significantly improve the symptoms of SIRS.Xuebijing injection might play an important role in treating AOPP patients.