骨髓异常增生综合征与急性髓性白血病的MRI表现

Bone marrow MRI of mylodysplastic syndrome and acute myeloid leukaemia

目的通过比较骨髓异常增生综合征(MDS)、急性髓性白血病(AML)患者和健康成人骨髓的MRI表现,探讨应用MRI预测MDS转化为AML的可能性。方法 MDS和AML各25例(MDS组、AML组),另选25名健康志愿者作为对照组。采用SET1WI及脂肪抑制序列T2WI,行腰椎矢状面、骨盆及股骨中上段骨髓正冠状面扫描,分析比较三组腰椎、髂骨和股骨近端的MRI表现差异。结果 MDS组、AML组患者骨髓MRI表现与对照组相比差异显著。MDS组与AML组腰椎、髂骨及股骨近端骨髓MRI表现差异无统计学意义。结论骨髓MRI可明确区分对照组与MDS组、AML组。骨髓MRI对预测和诊断MDS是否已经转化为AML的价值有限。

Objective To compare the bone marrow MRI manifestion of mylodysplastic syndrome （MDS）,acute myeloid leukaemia （AML） and normal volunteers,and to investigate the possibility of predict MDS progression to AML with MRI. Methods Twenty-five MDS patients （MDS group） and 25 AML patients （AML group） confirmed pathologically were selected. Twenty-five healthy volunteers were selected as normal control group. All subjects underwent bone marrow MR in sagittal lumbar,coronal iliac and proximal femur using SE T1W and T2W fat suppressed sequences. The bone marrow MRI manifestation of lumbar,iliac and proximal femur were analyzed and comared in three groups. Results There was significant difference in bone marrow MRI manifestation between MDS,AML and normal control group. No significant difference was found in bone marrow MRI manifestation between MDS and AML. Conclusion It is easy to differentiate bone marrow MRI of normal subjects from MDS and AML,but not easy to differentiate MDS and AML. It is difficult to predict MDS progression to AML solely with bone marrow MRI.