摘要
目的结合人体神经生理学、流体力学原理和电影相位对比磁共振成像(PC-MRI)特点,研究一种非侵入式无创性颅内压(ICP)测量方法。方法从颅内压强与颅内容积的一阶指数关系出发,推出单位容积内的颅内压强变化(弹性)与ICP之间成线性比例关系;利用速度编码的血液和脑脊液(CSF)的PC-MRI数据、压强变化与压强梯度变化间的关系,计算出弹性的值,最后根据弹性、弹性与ICP的线性关系式计算出ICP,并对2例颅脑疾病患者和3名健康人进行了试验测量。结果对2例颅脑疾病患者和3名健康人的测量均有效地估算出了ICP。结论基于PC-MRI的测量颅内压方法安全无创,对颅脑疾病患者和健康人ICP的测量均较为有效。
Objective To study a noninvasive intracranial pressure （ICP） measurement method basing on principles of human neural physiology,fluid dynamics and cine phase-contrast magnetic resonance imaging （PC-MRI）. Methods From the first-order exponential relationship of ICP and intracranial volume （ICV）,the linear relationship between pressure changes in the unit volume （elastance） and ICP could be derived. Using velocity encoded blood and cerebrospinal fluid （CSF） MR images and relationship between pressure gradient and pressure,elasticity was calculated. The value of ICP was estimated through elasticity and this linear relationship. ICP values of 2 patients with cranial disorders and 3 healthy volunteers were measured. Results ICP value of all the subjects were successfully estimated. Conclusion The above mentioned method is safe,noninvasive and efficient to both cranial disorder patients and healthy people in the measurement of ICP.
出处
《中国医学影像技术》
CSCD
北大核心
2010年第7期1350-1353,共4页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金(30470459)
西北工业大学基础研究基金(W018102)
关键词
颅内压
磁共振成像
弹性
脑脊髓液
Intracranial pressure
Magnetic resonance imaging
Elasticity
Cerebrospinal fluid
