间歇性低氧及游泳运动对大鼠右心室线粒体超微结构的影响

Influence on mitochondria ultrastructure of right ventricle during intermittent hypoxia and swimming exercise in rats

目的:观察间歇性低氧及游泳运动对大鼠右心室线粒体超微结构的影响,为高原医学的研究提供实验资料。方法:Wistar大鼠随机分为常氧对照组、低氧对照组和低氧运动组。用MPA-心功能分析系统记录血压和心率。用透射电镜观察右心室线粒体超微结构。结果:低氧对照组:大鼠肌原纤维间大量增生线粒体挤压变形,线粒体嵴和基质明显增多,线粒体间见大量空泡。线粒体排列无序,线粒体凝集变形。低氧运动组:肌膜下线粒体较多,线粒体排列有序。高倍镜下可见线粒体基质增多。结论:低氧对大鼠右心室线粒体的超微结构有一定的损伤,低氧及游泳运动对大鼠右心室线粒体超微结构有明显改善。

Objective：To observe the mitochondria ultrastructure of right ventricle during intermittent hypoxia and swimming exercise in rats to offer experimental data in plateau iatrical research.Method：Wistar rats were randomly divided into the normoxia control group,the hypoxia control group and the hypoxia training group.Blood pressure and heart rate were recorded by MPA-heart function analytical system.Mitochondria ultrastructure of right ventricle was observed by transmission electron microscope.Result：The hypoxia control group：Mitochondria hyperplasia,extruded deformation,mitochondrial crista and matrix increasing obviously and a great quantity vacuoles among mitochondria were found.Disarrangement and agglutinative deformation of mitochondria were also observed.The hypoxia training group：Mitochondria increasing under sarcolemma and arranging regularly were found.Mitochondrial matrix increasing could be observed under high power lens.Conclusion：The mitochondria ultrastructure of right ventricle was damaged during hypoxia,and the mitochondria ultrastructure of right ventricle improved significantly during intermittent hypoxia and swimming exercise.