期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

米诺环素在神经病理性疼痛治疗中的最新研究进展

The latest progress of minocycline in the treatment of neuropathic pain
原文传递
导出
摘要 神经病理性疼痛的发病机理复杂，所以其治疗困难。米诺环素是第二代半合成的四环素类药物，近年来的研究显示，此药可以抑制小胶质细胞的激活而减轻神经病理性疼痛以及阻止神经病理性疼痛的发展。本文就迄今为止米诺环素在神经病理性疼痛的研究作一综述。 The mechanism of neuropathic pain is complex. Therefore, its treatment is diffi cult. The latest investigations show that minocycline, which is a semisynthetic second generation tet racycline, can relieve neuropathic pain and prevent the development of neuropathic pain by inhibiting microglia activation. This article reviews the progress of minocycline in treatment of neuropathic pain so far.
作者 陈素昌 薛艳芝 张德仁
机构地区 深圳市南山区人民医院疼痛科 湖南株洲三三一医院麻醉科
出处 《实用疼痛学杂志》 2010年第3期217-220,共4页 Pain Clinic Journal
关键词 神经病理性疼痛 四环素 米诺环素 小神经胶质细胞 机理 Neuropathic Pain Tetracycline Minocycline Microglia Mechanism
分类号 R651.3 [医药卫生—外科学]
  • 相关文献

参考文献42

  • 1Niederberger E, Kuhlein H, Geisslinger. Update on the pathobiology of neuropathic pain. Expert Rev roteomics, 2008,5 (6) : 799 -818.
  • 2Koltzenburg M, Torebjork HE, Wahren LK. Nociceptive modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain, 1994,117 (pt 3) : 579-591.
  • 3Ro LS, Chang KH. Neuropathic pain: mechanisms and treatments. Chang Gung Med,2005, 289:597-605.
  • 4Macdonald H, Kelly RG,Allen ES, et al. Pharmacokinetic studies on minocycline in man. Clin Pharmacol Ther, 1973, 14(5): 852-861.
  • 5Carney S, Butcher R A, Dawborn J K, et al. Minocycline excretion and distribution in relation to renal function in man. Clin Exp Pharmacol Physiol, 1974,1 (4) : 299-308.
  • 6Zemke D, Majid A. The potential of minocycline for neuroprotection in human neurologic disease. Clin Neuropharmacol, 2004, 27(6): 293-298.
  • 7Brundula V, Rewcastle NB, Metz LM, et al. Targeting leukocyte MMPs and transmigration: minoeycline as a potential therapy for multiple sclerosis. Brain, 2002, 125(pt 6):1297-1308.
  • 8Li WW, Setzu A, Zhao C et al. Minoeycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination. J Neuroimmunol, 2005, 158(1-2): 58-66.
  • 9Pi R, Li W, Lee NT, et al. Minocycline prevents glutamateinduced apoptosis of cerebellar granule neurons by di{{erential regulation of P28 and AKT pathways. J Neuroehem, 2004,91 (5):1219-1230.
  • 10Stirling DP, Khodarahmi K, Liu J, et al. Minocycline treatment reduces delayed oligodendrocyte death attenuates axonal dieback and improves functional outcome after spinal cord injury. J Neurosci,2004,24(9) :2182-2190.
实用疼痛学杂志
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部