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甲状腺素对小鼠毛发生长周期的影响 被引量:2

The effect of thyroxin on mice hair cycle
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摘要 利用C57BL6小鼠作动物模型,观察甲状腺素对毛发生长周期的影响。选择毛发处于休止期的C57BL6小鼠,用不同剂量的左旋甲状腺素钠(T4)连续灌胃28d,并以松香/蜡混合物对小鼠背部皮肤进行拔毛诱导生长期作对照。结果,小鼠在拔毛后第6d皮肤变黑(生长期),黑色持续14d再次变粉红色(休止期)。喂甲状腺素钠125μg/d,625μg/d和3125μg/d的3组小鼠,分别在喂药第25d,第7d和第8d皮肤变黑,黑色亦持续14d左右。表明,左旋甲状腺素钠能够诱导小鼠毛发由休止期进入生长期。 In this study, C57BL6 mice were used as animal model to investigate the effect of thyroxin on hair cycle Normal C57BL6 mice with hair in telogen were selected, and were fed with different dosages of L thyroxin sodium(T4) for 28 days Anagen was induced over the back of telogen mice by depilation of hair shafts with wax/resin mixtare as control The results showed that the wax/resin treated skin turned to black(anagen) on day 6 after depilation, and turned to pink (telogen) again after 14 days The skin of mice fed with different dosages of T4 (1 25μg/day, 6 25μg/day and 31 25μg/day) turned to black on day 25, day 7 and day 8 respectively The skin also kept black about 14 days It suggests that T4 can stimulate the hair of C57BL6 mice from telogen to anagen
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 1999年第1期6-7,共2页 Journal of Clinical Dermatology
基金 P&G资助课题
关键词 左旋甲状腺素钠 毛发生长周期 甲状腺素 小鼠 L thyroxin sodium Hair cycle C57BL6 mice
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