化学纯三聚氰胺膀胱结石大鼠模型的研究

Studies on Rat Bladder Stone Model Caused by Chemical Pure Reagent of Melamine

为了探讨三聚氰胺形成泌尿系结石机理,进行化学纯三聚氰胺膀胱结石大鼠模型的研究.SD大鼠(以下简称大鼠)分别给予0.1、0.2、0.3、0.4、0.5、0.6、0.7、0.8、0.9、1.0g/(kg·d)剂量的化学纯三聚氰胺灌胃.溶媒对照组用10g/L甲基纤维素溶液5mL/(kg·d)灌胃,无菌水对照组用无菌水5mL/(kg·d)灌胃.在灌胃20、30和40d,每组各取10只大鼠(雌雄各半)剖检.结果表明,三聚氰胺灌胃大鼠,会影响其体质量的增长,部分大鼠形成膀胱结石(膀胱结石形成率最高为40%,雄性大鼠多见).

To investigate the mechanism of melamine urinary stone, the rat bladder stone model caused by chemical pure reagent of melamine were researched. Rats were fed 0. 1,0.2,0. 3,0. 4,0.5,0. 6,0. 7, 0. 8,0.9,1.0 g/（kg · d） chemical pure reagent of melamine. Vehicle control group was fed 10 g/L methyl cellulose solution 5 mL/（ kg· d）, sterile water control group was fed sterile water 5 mL/（ kg · d）. In the administration of 20,30 and 40 d,ten rats from each group （half male and half female） were examined post-mortem. Melamine would affect the growth of rat body mass, some rats had formed bladder stones （bladder stone formation rate was up to 40% , male rats were more common）.