早期肾性视网膜病变的视网膜电图改变

ERG changes in patients with early renal retinopathy

目的探索肾病变眼部并发症早期视网膜功能的损害程度及其规律，以寻求对肾病患者视功能的有效保护措施。方法对肾病住院患者３７人７４眼眼底检查有早期肾性视网膜病变者进行了视网膜电图（ＥＲＧ）检测，同时以健康者３５人７０眼作对照组。结果１．肾病组ＥＲＧｂ波波幅（３６０．６６±８１．８９μＶ），明显低于对照组（４３６．８±７１．０８μＶ），（Ｐ＜０．０１）；２．肾病组ＥＲＧ异常的发生率为５６眼（６２．１６％）明显高于对照组的１３眼（１８．５７％）（Ｐ＜０．００１）；３．不同肾病变各组ＥＲＧｂ波幅相比较无明显差异；４．肾病变者不同眼底改变各组（Ａ组：３７０．８１±７０，８４μＶ，Ｂ组：３５０．０６±８３．７６μＶ，Ｃ组：３４３．８６±１０８．８９μＶ）与对照组相比ｂ波幅明显降低（Ｐ＜０．０１）。结论ＥＲＧｂ波幅值的降低反映了肾性视网膜病变的早期功能改变。

ObjectiveTo investigate the degree and frequency of early functional damage to the retina due to ocular complications of kidney disease,and to explore early effective treatments and ways to prevent functional retinal damage in patients with kidney disease.Methods37 cases(74 eyes)of patients with early renal retinopathy were examined by electroretinogram(ERG).35 cases(70 eyes)of healthy subjects were taken as the normal control.ResultsIn the kidney disease group,the b wave amplitudes(360.66± 81.89 μV) were significantly lower than those of the control group(436.8±71.08μV)( P <0.01).The frequency of abnormal ERG(56 eyes, 62.16% )was significantly higher than that of control group(13 eyes,18.57%)( P <0.01).The b wave amplitudes among different groups with kidney disease patients showed no marked differences.The b wave amplitudes of groups with different ocular fundus changes (Group A∶370.81±70.84μV;Group B∶350.06±83.76μV;Group C∶343.86±108.89μV)were markedly decreased as compared with those of the normal control group(Control group∶436.8±71.08μV).ConclusionThis study indicates that the decrease of ERG b wave amplitude is reduced in early renal retinopathy,reflecting early functional damage to the retina.This study has reference value to evaluate retinal function in patients with organic retinal damage due to renal retinopathy.