血清TGF β1浓度与胃癌侵袭性及其根治手术的关系探讨

Relationship between Serum Concentration of TGF 1 with Aggressiveness of Cancer in Radical Resection of Gastric Cancer

目的：探讨ＴＧＦβ１对人胃癌侵袭性的作用。方法：应用酶联免疫吸附法测定２９例胃癌病人血清转化生长因子（ＴＧＦ）β１浓度。结果：浸润型组或伴有淋巴结转移组的血清ＴＧＦβ１浓度分别明显高于膨胀型组或无淋巴结转移组（Ｐ＜０．０５～０．０１），切除瘤体后上述各组的血清ＴＧＦβ１浓度均明显下降（Ｐ＜０．０５～０．０１）。结论：ＴＧＦβ１可能与人胃癌的浸润和转移密切相关。

Objective: To study the activity of transforming growth factor 1 (TGF 1) on aggressiveness of human gastric cancer. Methods: Using ELISA technic fasting concentration of serum TGF 1 was determined in 29 patients with gastric cancer before and after radical operation. Results: The serum TGF 1 concentration was significantly higher in patients with invasive gastric cancer or with lymph node metastasis than those with cancers with expansive growth pattern or without lymph node involvement (P< 0.050.01). The serum TGF 1 level dropped markedly after the removal of tumor of the latter two groups of patients (P< 0.050.01). Conclusion: TGF 1 might be closely correlated with the aggressiveness and metastasis of gastric cancer.