原发性肝癌患者血浆D-二聚体测定与肿瘤临床分期关系探讨

Study on Relationship between Plasma D-dimer Concentration and Clinical Staging of Primary Hepatic Cancer Ouyang Xuenong Chen Zhangshu Tu Xiaohuang et al

目的：探讨Ｄ二聚体（Ｄｄｉｍｅｒ）变化与原发性肝癌临床分期关系。方法：采用酶联免疫吸附反应检测了８５例不同临床分期肝癌患者血浆Ｄ二聚体含量。结果：各临床分期肝癌患者Ｄ二聚体均显著高于对照组（Ｐ＜００１），且不同临床分期肝癌患者之间，Ｄ二聚体含量相差非常显著（Ｐ＜００１）。随肝癌患者病情加重，转移发生，Ｄ二聚体呈递增趋势，在Ⅲ期患者，Ｄ二聚体１００％升高。结论：Ｄ二聚体不仅可以反映患者呈现不同程度的纤溶亢进，而且可以作为肝癌患者预后判断的指标。

To study the relationship between plasma D-dimer changes and clinical staging of primary hepatic cancer, ELISA was used to determine the concentration of D-dimer in 85 patients with hepatic cancer of different stages. The patients were divided into three groups (stage I , II and III ). The results showed that the D-dimer level of all these three groups were significantly higher than that in the control group (P< 0.01) and that there were differences between the groups,increasing markedly with upgrading of the stage. The positive rate of D-dimer was 100%in stage III group. The results indicate that abnormal increasing of D-dimer level not only means a high viscosity and active fibrinolysis but also predicts the poor prognosis of hepatic cancer.