摘要
目的:考察龙脑对多种药物透皮作用的影响。方法:以改良的Frang双室渗透扩散装置进行药物体外渗透试验;以家兔在体试验和人体皮肤苍白试验进行药物活体透皮试验。结果:在离体蛇蜕透皮吸收试验,龙脑增加甲硝唑、氟脲嘧啶的透皮吸收,存在剂量效应关系;在志愿者前臂内侧皮肤,龙脑提高醋酸曲安奈德的生物利用度;在整体兔,龙脑使水杨酸经皮吸收增加。
OBJECTIVE:To observe the effects of borneol affecting the transdermal amount of drugs.METHODS:Drugs permeation tests were performed in a two compartment diffusion cell through cobra skin in vitro,in rabbits and on the human skin blanching assay in vivo ,respetively.RESULTS: In vitro ,borneol increased the percutaneous transport of metronidazole and 5 fluorouracil.The potency of 3 0% borneol was different from that of 1 0%borneol.On the human skin beanching assay in vivo it indicated that borneol enhanced the bioavailability of percutaneous penetration of triamcinolone acetonide acetate.In rabbits,borneol increased AUC o~12h of salicylic acid in plasma.CONCLUSION:It indicated borneol is a effective percutaneous penetration enhancer.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
1999年第2期104-106,共3页
Chinese Pharmaceutical Journal