多靶点治疗狼疮性肾炎的临床分析

Clinical anglysis of multi-target treatment of lupus nephritis

目的:探讨多靶点治疗狼疮性肾炎的临床疗效。方法:回顾性分析本院收治的狼疮性肾炎患者46例的临床资料,依据肾炎治疗方式分为普通观察组(23例)和多靶点对照组(23例)。普通观察组在整个治疗过程中给予环磷酰胺加入0.9%氯化钠注射液中静滴或静注。而多靶点对照组采用多靶点+强的松药物,并在治疗中加用环磷酰胺(CTX)。结果:多靶点对照组治疗效果优于普通观察组,多靶点对照组总治愈率为91.3%,普通观察组治愈率为34.78%。结论:在整个治疗过程中运用多靶点+强的松的稳固治疗,为狼疮性肾炎患者减轻了疾病上的疼痛,治愈率高,安全性大。所以,多靶点治疗在临床上是有效、可观的治疗方法,是值得临床推广的一种治疗方法。

Objective：To investigate the clinical effect of the multi-target treatment of lupus nephritis.Methods：Retrospective analysis of patients with lupus nephritis were treated 46 cases of clinical data,based on general observation of nephritis were divided into treatment group （23 cases） patients,and multi-target control group （23 cases） patients.General observation group in the whole course of treatment for cyclophosphamide 0.9% sodium chloride injection or intravenous infusion. The multi-target control group,multi-target and prednisone drug, the treatment was added in CTX.Results：The multi-target control group was superior to the observation group,multi-target control group cure rate was 91.3% ,general observation group the cure rate was 34.78%.Conclusion：The use of the entire course of treatment,the stability of multi-target and prednisone therapy for patients with lupus nephritis to reduce the pain of disease,high cure rate,safety,great.Therefore,the multitarget therapy is clinically effective and substantial treatment is worth promoting as a medical treatment.