脂联素/高敏C-反应蛋白比值对冠心病严重程度的预测价值

Predictive value of adiponectin/high sensitivity C-reaction protein ratio on coronary artery diseases severity

目的:评估脂联素/高敏C-反应蛋白比值对冠心病严重程度的预测价值。方法:收集78例确诊为冠心病的患者,将其分为稳定型心绞痛组、急性冠脉综合征组及ST段抬高型心肌梗死组3组,检测空腹静脉血浆高敏C-反应蛋白及脂联素水平,并计算脂联素/C-反应蛋白比值,分析冠心病患者血浆脂联素/C-反应蛋白比值与冠心病严重程度的相关性。同时收集30例健康者作为对照组。结果:冠心病患者血浆高敏C-反应蛋白水平均明显高于对照组(P<0.05),但急性冠脉综合征及ST段抬高型心肌梗死组间无差别;急性冠脉综合征及ST段抬高型心肌梗死组APN水平均明显低于对照组(P<0.05),稳定型心绞痛组与对照组无差别;脂联素/C-反应蛋白比值随冠心病严重程度逐渐增加而减低(P<0.05)。spearman等级相关分析提示脂联素/C-反应蛋白比值与冠心病严重程度相关性最大,r=-0.978。结论:血浆脂联素/C-反应蛋白比值对冠心病严重程度具有较好的预测价值。

Objective： To investigate the predictive value of adiponectin （APN）/High sensitivity C-reaction protein （Hs-CRP） ratio on coronary artery diseases severity. Methods： 78 patients with coronary artery diseases were divided into stable angina, acute coronary syndrome and ST elevation myocardial infarction groups.Fasting venous blood was used to detect Hs-CRP and APN level.APN/Hs-CRP ratio was calculated and used to evaluate the relationship between the APN/Hs-CRP ratio and coronary artery diseases severity. We also enrolled 30 healthy participants as a control group. Results： Hs-CRP level in coronary artery disease groups were significant higher than control group （P0.05） but there was no difference between ACS and STEMI groups. APN level was significant lower in ACS and STEMI groups （P0.05）whereas there was no difference between SA and control group.APN/Hs-CRP ratio gradually decreases accompanying with the increased severity of coronary artery diseases.The relationship between APN/Hs-CRP ratio and coronary artery diseases severity was strongest （r=-0.978） indicating by spearman analysied. Conclusion： Serum APN/Hs-CRP ratio has a well predictive value on coronary artery diseases severity.