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神经生长因子受体在子宫腺肌病中的表达及意义 被引量：3

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摘要 目的了解神经生长因子受体(tyrosine kinase,TrkA)在子宫腺肌病痛经患者异位内膜、在位内膜中的表达情况。方法采用免疫组化抗生物素蛋白-过氧化物酶染色法(S-P法)检测子宫腺肌病痛经患者(研究组)20例异位内膜、在位内膜及对照组22例子宫肌瘤无痛经患者子宫内膜中神经生长因子受体的表达,并进行比较分析。结果 TrkA在研究组异位内膜及在位内膜中的表达差异无显著性意义(P>0.05),但二者TrkA的表达强度均显著高于对照组子宫内膜(P<0.01)。研究组异位内膜增殖期高于分泌期[(3.25±0.82)vs(1.93±0.94),P<0.05],研究组在位内膜及对照组内膜增殖期与分泌期比较,差异均无统计学意义(P>0.05)。研究组痛经程度与TrkA的表达呈正相关(r=0.539,P<0.05)。结论 TrkA在子宫腺肌病痛经患者异位内膜及在位内膜中广泛表达,可能在子宫腺肌病发病及痛经发生中起重要作用。
作者 李建勇 瞿全新 李宝江
机构地区 天津市第五中心医院妇产科 天津市第一中心医院妇产科 天津市第五中心医院病理科
出处 《第三军医大学学报》 CAS CSCD 北大核心 2010年第14期1570-1572,共3页 Journal of Third Military Medical University
关键词 神经生长因子受体 子宫腺肌病 痛经 免疫组化
分类号 R711.710.2 [医药卫生—妇产科学] R446.8 [医药卫生—诊断学]
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参考文献13

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共引文献550

同被引文献17

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第三军医大学学报
2010年 第14期

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