依替二膦酸锶对去势大鼠骨代谢的影响

The effects of the strontium etidronate on bone metabolism in ovariectomized rats

目的观察新合成的抗骨质疏松化合物--依替二膦酸锶对骨代谢的影响。方法本研究以去势SD大鼠为基础,对依替二膦酸锶、依替二膦酸二钠和二氯化锶以及不同剂量依替二膦酸锶对大鼠血清骨钙素(BGP)和血清抗酒石酸酸性磷酸酶5b(TRAP-5b)的影响进行动态观察和比较。结果药物干预治疗后,依替二膦酸锶治疗组其血清TRAP-5b均逐渐下降,与去势对照组的相比表现出明显统计学差异;依替二膦酸锶150mg/kg·d治疗组,其血清BGP有缓慢上升的趋势,于12w末与去势对照组相比差异表现出显著的统计学意义。结论依替二膦酸锶50mg/kg·d、100mg/kg·d和150mg/kg·d治疗剂量均能有效抑制破骨细胞分泌TRAP-5b的能力。依替二膦酸锶150mg/kg·d治疗剂量可能有助于增强绝经期后骨质疏松大鼠成骨细胞分泌BGP的能力。

Objective In order to investigate the effects on bone metabolism of the new compound （strontium etidronate）. Methods We observed and compared the serum osteocalcin （BGP） and tartrateresistant acid phosphatase 5b （TRAP-Sb） changes of ovariectomized SD rats coped with didodium etidronate, strontium chloride and different doses strontium etidronate. Results Strontium etidronate could decrease the serum TRAP-Sb of the ovariectomized rats, and show the statistical difference; and the 150 mg/ kg·day, strontium etidronate could improve the serum BGP steadily, and the statistical difference appeared after being coped with 12 w. Conclusion Strontium etidronate in different doses 50 mg/kg · day,100 mg/ kg·day and 150 mg/kg·day, all could suppress the TRAP-Sb secretion ability of osteoclasts; and the dose of 150 mg/kg·day maybe improve the BGP secretion ability of osteoblasts.