药物干预类风湿关节炎关节畸形的研究进展

Advances in drugs on preventing joint destruction of rheumatoid arthritis

大量研究表明,抗CCP抗体及抗Sa抗体阳性RA患者关节畸形的发病率明显高于阴性患者。近几年来,在研究干预RA关节畸形的药物方面也有很好发展,其中有TNF-α拮抗剂、IL受体拮抗剂、MMP抑制剂、血管内皮生长因子、MTX、激素及植物药等,但因生物制剂价格高昂,使其临床广泛应用及长期疗效观察一直难以实现,而植物药因其独特的优势在干预RA关节畸形等方面越来越受到风湿学家们的青睐。

A growing body of evidence has shown that patients with Anti-Cyclic Citrullinated Peptide and Anti-Sa antibodies positive had significantly higher incidence of joints destruction than that not. During the last decades, the drugs preventing joint destruction have been well established, containing anti-tumor necrosis factor antagonist, interleukin receptor antagonist, matrix metalloproteinase inhibitor, vascular endothelial growth factor, methotrexate, glueocorticoids and Chinese Medicine. However, the biological agents are too expensive to widespread application and long-term clinical observation, while the Chinese Medicine for its distinct advantages in preventing joint destruction is becoming a focal point for rheumatologist study.