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脑卒中后免疫抑制 被引量:9

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摘要 临床观察发现很多患者脑卒中后发生感染,随着对其免疫状态的观察和研究,脑卒中后免疫抑制被逐渐认识。脑卒中后免疫抑制的机制可能是免疫抑制信号通过下丘脑-垂体-肾上腺皮质轴及自主神经系统下传至周围免疫系统而导致全身免疫状态变化。脑卒中后免疫抑制可引起全身免疫功能下降,但对于脑卒中后的脑组织可能具有保护作用。有关脑卒中后免疫抑制的研究对预测患者的预后,预防脑卒中后感染甚至减少梗死面积,改善预后等具有重要意义。
出处 《中国神经免疫学和神经病学杂志》 CAS 2010年第4期297-299,共3页 Chinese Journal of Neuroimmunology and Neurology
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  • 1Clausen BH, Lambertsen KL, Babcock AA, et al. Interleukin lbeta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice[J]. Neuroinflammation, 2008, 5: 46.
  • 2Pasarica D, Gheorghiu M, Topgrceanu F, et al. Neurotrophin-3, TNF-alpha and IL-6 relations in serum and cerebrospinal fluid of ischemic stroke patients[J]. Roum Arch Microbiol Immunol, 2005, 64(1-4):27 33.
  • 3Emsley HC, Smith CJ, Tyrrell PJ, et al. Inflammation in acute ischaemie stroke and its relevance to stroke critical care [J]. Neurocrit Care, 2008, 9(1): 125-138.
  • 4Dirnagl U, Klehmet J, Braun JS, et al. Stroke-induced immunodepression: experimental evidence and clinical relevance [J]. Stroke, 2007, 38: 770-773.
  • 5Prass K, Meisel C, Hoflich C, et al. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by post-stroke T helper cell type 1-like immunostimulation [J]. Fxp Med, 2003, 198:725-736.
  • 6Vogelgesang A, Grunwald U, Langner S, et al. Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke[J]. Stroke, 2008, 39: 237-241.
  • 7Klehmet J, Harms H, Richter M, et al. Stroke induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial[J]. Neuroscience, 2009, 158(3):1184-1193.
  • 8Offner H, Subramanian S, Parker SM, et al. Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages[J]. Immunol, 2006, 176: 6523-6531.
  • 9唐方,陈槐卿,徐朝义,张峻梅,高励,刘凯.急性缺血性脑卒中患者外周血白细胞CD11b、CD18表达变化研究[J].中国神经免疫学和神经病学杂志,2003,10(2):119-122. 被引量:2
  • 10Prass K, Braun JS, Dirnagl U, et al. Stroke propagates bacterial aspiration to pneumonia in a model of cerebral isehemia [J]. Stroke, 2006, 37:2607-2612.

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