体重指数对血糖、血脂及血压的影响

Effect of different BMI level on blood glucose,lipid and blood pressure

目的探讨不同体重指数(BMI)水平对血糖、血脂及血压的影响。方法对1568例年龄≥20岁的健康体检者的资料进行统计学分析,按BMI不同分为四组:G1组(BMI≤18.5 kg/m2)、G2组(18.5 kg/m2<BMI≤23.9 kg/m2)、G3组(24 kg/m2≤BMI≤27.9 kg/m2)和G4组(BMI≥28 kg/m2)。结果随BMI逐渐升高,收缩压、舒张压、空腹血糖(FPG)、餐后2 h血糖(PG 2 h)、总胆固醇、甘油三酯(TG)、低密度脂蛋白胆固醇均呈线性上升趋势,而高密度脂蛋白胆固醇呈下降趋势,组间比较差异有统计学意义。在G3组,FPG(6.2±0.4)mmol/L,PG 2 h(8.1±1.3)mmol/L,但血压和TG尚正常,G4组FPG(6.5±0.3)mmol/L,PG 2 h(9.0±1.6)mmol/L,血压均值139.5/88.3 mm Hg(1 mm Hg=0.133 kPa),TG(1.8±1.0)mmol/L。经Logistic逐步回归分析,G3及G4组均与糖尿病、高甘油三酯血症和高血压病呈独立正相关关系。结论 BMI≥24 kg/m2后发生糖尿病、高甘油三酯血症及高血压病的危险性大大增加。

Objective To explore the effect of different BMI level on blood glucose,lipid and blood pressure.MethodsClinical data of 1568 subjects aging over 20 years were analyzed.They were divided into 4 groups according to BMI level,which were BMI≤18.5 kg/m^2,18.5-23.9 kg/m^2,24-27.9 kg/m^2 and ≥28 kg/m^2.ResultsWith BMI increasing,the level of fasting plasma glucose（FPG）,2 h-plasma glucose after OGTT（PG 2 h）,blood pressure（BP）,total cholesterol（TC）,triglycerides（TG） and lowdensity lipoprotein-cholesterol（LDL-C） showed a trend of linear increase,but highdensity lipoprotein-cholesterol（HDL-C） showed a trend of linear decrease,and there were significant differences among the groups.The mean FPG and PG 2 h in group with BMI 24-27.9 kg/m^2 reach（6.2±0.4）mmol/L and（8.1±1.3）mmol/L respectively,but BP and TG were still normal range.In group with BMI ≥28 kg/m^2,FPG and PG 2 h were（6.5±0.3）mmol/L and（9.0±1.6）mmol/L respectively,the mean BP was 139.5/88.3 mm Hg（1 mm Hg=0.133 kPa）,the mean fasting TG was（1.82±1.0）mmol/L.Logistic regression analysis showed that BMI in the group of 24-27.9 kg/m^2 and ≥28 kg/m^2 were positively associated with the development of DM,hypertriglyceride and hypertention.ConclusionWhen BMI is over 24 kg/m^2,the risk of development of DM,hypertriglyceride and hypertention should significantly increased.