HEAG基础方案治疗难治性/复发性急性白血病的疗效

Effects of HEAG regimen on patients with refractory/recurrent acute leukemia

目的探讨HEAG为基础的方案治疗难治性/复发性急性白血病的疗效。方法高三尖杉酯碱(Hht)1～2 mg/(m2.d),第1～14天;阿糖胞苷(Ara-C)30 mg/(m2.d),第1～14天;粒细胞集落刺激因子(G-CSF)150μg/(m2.d),第1～14天;可根据患者情况加用足叶乙甙(VP-16)50～100 mg/(m2.d),第1～4天;组成HAEG方案,治疗23例难治性/复发性急性白血病,观察疗效。结果完全缓解12例(52.2%),部分缓解2例(8.7%),总有效率为60.8%。结论 HEAG为基础的方案治疗难治性/复发性急性白血病有较满意的疗效。

Objective To explore the therapeutic protocol for patients with refractory/recurrent acute leukemia.MethodsTwenty-three cases of refractory acute leukemia were treated with HEAG regimen,which consisted of Hht 1-2 mg/（m^2·d）（d1～14）,Ara-C 30 mg/（m^2·d）（d1～14）,G-CSF 150 mg/（m^2·d）（d1～14）,and VP-16 50 ～100 mg/（m^2·d）（d1～4）.ResultsTwelve patients（52.2%）achieved complete remission,2 patients（8.7%）did partialremission,overan effective rate was 60.8%.ConclusionHEAG regimen in treatment of refractory/recurrent acute leukemia is an effective means.