不同频率电针对急性实验性关节炎大鼠痛阈及血浆环核苷酸和皮质醇含量的影响

Effects of Electroacupuncture at Different Frequencies on Pain Threshold and Contents of Plasma Cyclic Nucleotides and Cortisol in Rats of Acute Experimental Arthritis

观察两种频率（５Ｈｚ和１００Ｈｚ）电针对急性佐剂性关节炎大鼠压力缩肢阈及血浆ｃＡＭＰ、ｃＧＭＰ和皮质醇含量的影响。结果表明，这两种频率电针均能明显升高关节炎大鼠痛阈，但两者的作用无明显差异；这两种频率电针均能提高血浆ｃＡＭＰ和ｃＧＭＰ含量，两者对血浆ｃＧＭＰ含量的升高作用有非常显著的差异；５Ｈｚ电针镇痛效应与血浆ｃＡＭＰ含量有显著相关；５Ｈｚ电针能明显升高血浆皮质醇含量。提示不同频率电针可产生不同效应。

Effects of electroacupuncture at two different frequencies,5Hz and 100Hz on pressure induced limb withdrwaing latency and contents of plasma cAMp,cGMp and cortisol were observated.Results showed that electroacupuncture at the two frequencies all could increase obviously pain threshold in the rats of arthritis,with no significant difference between them;electroacupuncture at the two frequencies all could raise plasma cAMP and cAMP contents,with significant difference between the two frequencies;the analgesic effect of electroacupuncture at 5Hz had significant correlativity with the increase of plasma cAMP content;and electroacupuncture at 5Hz could elevate markedly plasma cortisol content.It is suggested that electroacupuncture at different frequencies can produce different effects and they have possibly different analgesic mechanisms.