依那普利治疗原发性高血压的临床观察

The Efficacy of Enalapril in Patients with Essential Hypertenion

本文对68例原发性高血压患者,随机分为两组。观察依那普例(enalapril)的降压效果,并与巯甲丙脯酸进行比较。依那普利组共44例;巯甲丙脯酸对照组24例。结果依那普利的降压有效率为86.4%,降压幅度为21.2/14.4mmHg,与巯甲丙脯酸的疗效相似。无明显不良反应。依那普利的半衰期和降压作用持续时间较长。每天服药一次或二次,即能控制24 h血压,较巯甲丙脯酸更方便于病人应用。

In a randomized, blind trial, enalapril and captopril were compared in 68 patients with essential hypertension. Before trial, patients' age, duration of hypertension and the level of blood pressure of the two groups were comparable. The results showed that enalapril and captopril had similar effects on the blood pressure, with a response rate of 86.4% and 83.3% respectively. Blood pressure reduced 21.2/14.4mmHg in enalapril group versus 19.2/13.1 mmHg in captopril group. No serious side effects were observed and both drugs were well tolerated. Thus, enalapril and captopril appear equally effective and safe in patients with essential hypertension. Enalapril is more convenient for use because of its longer duration of antihypertensive activity.