心得安、美多心安对人体安替比林代谢的影响

The Influence of Propranolol and Metoprolol on Antipyrine Metabolism in Human

该实验选择22例正常受试者随机分成两组,一组口服心得安10 mg每日3次,另一组口服美多心安25mg每日二次,历时均一周,在用药前后均作安督比林试验,结果表明心得安组安替比林半衰期明显延长(从18.51±3.21 h延长至21.22±4.92 h,p<0.05);清除率降低(从0.02182±0.00504L/h降低至0.01938±0.00591L/h,p<0.05);分布容积无变化(0.5594±0.0759 L/kg～0.5647±0.0781 L/kg,p>0.05)。而美多心安组对安替比林代谢影响较小。

Twenty two healthy volunteers were randomly allotted to two groups. One group took oral propranolol 10 mg thrice daily and the other took metoprolol 25 mg twice daily for one week. Antipyrine test was done before and after the course. The results showed that after taking drug, the halt-life of antipyrine in propranolol group increased from the original 18.51±3.21 h to 21.22±4.92 h (P<0.05), while the clearance rate decreased to 0.01938±0.00591 L/h from a pre-drug level of 0.02182±0.00504 L/h (P<0.05). No change was found in terms ef volume of distribution (P>0.05). The metoprolol group had less influenced on antipyrine metabolism.