深圳市2008年高龄产妇妊娠结局分析

Analysis on pregnancy outcomes of elderly pregnant women in 2008 in Shenzhen

目的:探讨深圳市高龄产妇与不良妊娠结局的关系,为妇幼卫生政策提供依据。方法:对深圳市妇幼信息系统2008年深圳市161362例产妇资料进行分析,采用单因素分析比较不同年龄段产妇基本状况及妊娠结局,采用多因素Logistic分析产妇高龄与早产及低出生体重的关系,分析软件使用SPSS15.0。结果:深圳高龄产妇的比例逐年上升;单因素分析表明,随产妇年龄的增加,初产妇比例下降,孕前超重、肥胖比例增加,剖宫产比例增加;40岁以上产妇分娩婴儿的平均出生体重显著低于30～34岁以及35～39岁产妇,平均孕周显著低于其他年龄组,早产儿、低出生体重儿、小于胎龄儿比例、围产儿死亡率在产妇各年龄段分布呈中间低两头高态势,极早早产儿、极低低出生体重儿比例均以40岁以上产妇比例最高,出生缺陷率随产妇年龄增加而增加。多因素分析显示,控制产妇户籍类型、产次、体质指数、小孩性别后,与20～29岁组相比,35～39岁组和≥40岁组产妇低出生体重儿和早产儿的危险性增加。结论:深圳市大样本研究表明产妇高龄与不良的妊娠结局有关。

Objective： To explore the relationship between elderly pregnant women and adverse pregnancy outcomes in Shenzhen, provide a basis for making maternal and child healthcare decisions. Methods： Data of 161 362 pregnant women in 2008 from Shenzhen maternal and healthcare computerized system were analyzed; single factor analysis was used to compare the basic conditions and pregnancy outcomes of pregnant women among different maternal age groups; multiple factors logistic analysis was applied to analyze the relationship between advanced maternal age and premature delivery,low birth weight,SPSS 15. 0 software was use in the study. Results： The proportion of elderly pregnant women increased year by year. Single factor analysis： with the increase of maternal age,the proportion of primiparous women decreased,the proportions of pregestational overweight and obesity increased,the rate of cesarean section increased; the average birth weight of neonates born by pregnant women over 40 years was significantly lower than those by pregnant women aged 30 ～ 34 years old and 35 ～ 39 years old,the average gestational weeks was significantly lower than the other age groups,the distributions of proportions of premature infants,low birth weight infants,small for gestational age infants and perinatal mortality showed a U shape among the age groups; the proportions of very early premature infants and very low birth weight infants in pregnant women over 40 years were the highest,the rate of birth defects increased with maternal age. Multiple factors logistic analysis： after controlling residential types,parity,BMI of pregnant women and baby＇s sex,compared to pregnant women aged 20 ～ 29 years old,the risk of premature infants and low birth weight infants increased in pregnant women aged 35 ～ 39 years old and pregnant women over 40 years. Conclusion： Advanced maternal age is related to adverse pregnancy outcomes.