有高血压家族史血压正常的青少年血清抵抗素测定及临床意义

Detection of serum resistin and clinical significance in normotensive adolescents with family history of hypertension

目的:探讨有高血压家族史但血压正常的青少年血清抵抗素的变化。方法:研究对象为30例有高血压家族史、本人血压正常的青少年(家族史阳性组,FH+组)和30例无高血压家族史、血压正常的青少年(对照组,FH-组),测定其身高、体重、体重指数(BMI)、血压、空腹血糖(FBG)、血总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)和血清抵抗素(Resistin)。结果:FH+组青少年的BMI、收缩压、FBG、TC、LDL-C和血清抵抗素均高于FH-组,差异有统计学意义(P<0.05)。血清抵抗素水平与收缩压(SBP)和FBG呈正相关(P<0.05)。结论:有高血压家族史的青少年即使在血压尚处于正常范围时,已发生血清抵抗素水平升高,血清抵抗素水平可能与血压相关。

Objective： To explore the changes of serum resistin in normotensive adolescents with family history of hypertension. Methods： 30 normotensive adolescents with family history of hypertension （ positive group,FH ＋ group） and 30 normotensive adolescents without family history of hypertension （ control group,FH group） were selected. Height,weight,body mass index （ BMI） , blood pressure,fasting blood glucose （ FBG） ,total cholesterol （ TC） ,cholesteroltriglyceride （ TG） ,low density lipoprotein cholesterol （ LDL C） ,high density lipoprotein cholesterol （ HDL C） and resistin were detected. Results： BMI,systolic blood pressure,FBG,TC, LDL C and serum resistin in FH ＋ group were significantly higher than those in FH group （ P 0. 05） . There was a positive correlation between serum resistin level and systolic blood pressure,FBG （ P 0. 05） . Conclusion： The level of serum resistin increases in normotensive adolescents with family history of hypertension. Serum resistin level may be related to blood pressure.