MMP-2和EGFR在胃癌中的表达及其与生物学特征的关系

The Expression of MMP-2 and EGFR in the Tissues from Gastric Carcinoma

目的探讨胃癌组织中EGFR与基质金属蛋白酶-2(MMP-2)的表达及其与胃癌生物学特征的关系。方法采用免疫组化方法检测64例胃癌原发灶标本中EGFR和MMP-2的表达,并观察其与胃癌生物学特征的关系以及EGFR与MMP-2表达的相关性。结果 64例胃癌组织中,EGFR和MMP-2的表达阳性率分别为31.3%(20/64)和68.8%(44/64);EGFR的过度表达与胃癌临床分期、有无淋巴结转移、TNM分期及组织分化程度相关(P<0.05);MMP-2的表达与胃癌临床分期、有无淋巴结转移及TNM分期亦相关(P<0.05),但与组织分化程度无明显相关(P>0.05);且EGFR的表达与MMP-2的表达存在相关性(P<0.05)。结论胃癌组织中EGFR的表达与MMP-2的表达密切相关,EGFR、MMP-2的表达水平可作为了解胃癌生物学行为和判断预后的指标。

Objective To evaluate the expression of EGFR and matrix metalloproteinase-2（MMP-2） in the tissues from gastric cancer and its relationship with the biological characteristics of gastric cancer.Methods The expression of EGFR and MMP-2 was detected by immunohistochemistry in the tissues from 64 patients with gastric cancer.Results The positive expression of EGFR and MMP-2 was 31.25%（20/64） and 68.75%（44/64）;EGFR over-expression was related to the clinical stage,lymph node metastasis,TNM stage and the degree of differentiation（P〈0.05）;MMP-2 over-expression was related to the clinical stage,lymph node metastasis and TNM stage（P〈0.05）,but was not related to the degree of differentiation（P〉0.05）;The expression of EGFR and MMP-2 was positively correlated（P〈0.05）.Conclusion The expressions of EGFR and MMP-2 was correlated in the tissues from gastric cancer.