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Pokemon mRNA在乳腺癌组织中的表达及意义 被引量：3

Expression and Clinical Significance of Pokemon mRNA in Breast Cancer
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摘要 目的探讨乳腺癌组织中Pokemon mRNA的表达及其意义。方法采用原位杂交法,检测45例乳腺癌、20例癌旁乳腺组织、20例正常乳腺组织中Pokemon mRNA的表达,并对其与乳腺癌临床病理特征的关系进行分析。结果 Pokemon mRNA主要表达于乳腺癌细胞质。乳腺癌组织中Pokemon mRNA表达率为71.11%(32/45),显著高于癌旁乳腺组织30.00%(6/20)和正常乳腺组织20.00%(4/20),P<0.05。有腋窝淋巴结转移组Pokemon mRNA表达率(90.00%)显著高于无腋窝淋巴结转移组(56.00%),P<0.05。组织学分级Ⅲ级组织Pokemon mRNA表达率(100.00%)显著高于Ⅰ级组织(53.33%),P<0.05。结论 Pokemon mRNA过度表达可能在乳腺癌发生中起重要作用,且与腋窝淋巴结转移及其组织学分级相关。 Objective To investigate the expression and significance of Pokemon mRNA in breast cancer.Methods The expression of Pokemon mRNA was detected by using in-situ hybridization（ISH）in 45 cases of breast cancer,20 cases of adjacent noncancerous breast tissues and 20 cases of mammary gland hyperplasia.The clinical and histopathological records were retrospectively analyzed.Results Pokemon mRNA was located in the plasma of breast cancer cells.The rate of strong positive plasma Pokemon mRNA expression was significantly higher in breast cancer than in adjacent noncancerous breast tissue and mammary gland hyperplasia（P〈0.05）,and the rate of strong positive plasma Pokemon mRNA expression was 71.11%（32/45）,30.00%（6/20）,20.00%（4/20）,respectively;The rate of strong positive plasma pokemon expression was significantly higher in breast cancer with axillary lymph node metastasis（90.00%）than in that without axillary lymph node metastasis（56.00%）,P〈0.05）.The histology III gradeThe pokemon mRNA expression was significantly higher in grade Ⅲ（100.00%） than that in grade Ⅰ（P〈0.05）.Conclusion Overexpression of Pokemon mRNA is probably related to the carcinogenesis and axillary lymph node metastasis and histology grade of primary breast cancer.
作者 付朝江 崔明
机构地区 昆明医学院第三附属医院 云南省肿瘤医院ICU 成都军区昆明总医院普通外科
出处 《实用癌症杂志》 2010年第4期361-363,共3页 The Practical Journal of Cancer
关键词 乳腺癌 原位杂交 Breast cancer In-situ hybridization（ISH）
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Maeda T,Hobbs RM,Merghoub T,et al.Role of the proto-oncogene pokemon in cellular transformation and ARF repression[J].Nature,2005,433:278.
  • 2Pessler F,Pendergrast PS,Hernandez N.Purification and c-haracterization of FBI-1,a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts[J].Mol Cell Biol,1997,17(7):3786.
  • 3Chen WY,Zeng X.Heterozygous disruption of Hic1predis-poses mice to a gender-dependent spectrum of malignant tumors[J].Nat Genet,2003,33:197.
  • 4Maeda T,Hobbs RS,Merghoub T,et al.Role of the protooncogene Pokemon in cellular transformation and ARF repression[J].Nature,2005,433(7023):278.
  • 5车轶群,王海,齐军,郭健,刘芝华.食管鳞癌组织中SPARC蛋白表达的临床意义[J].中国肿瘤临床,2006,33(2):61-63. 被引量：12
  • 6Naidu R,Wahab NA,Yadav M,et al.Protein expression and molecular analysis of c-Myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chainreaction[J].Int J Mol Med,2002,9:189.
  • 7Maeda T,Hobbs RM,Merghoub T,et al.Role of the proto-oncogene pokemon in cellular transformation and ARF repression[J].Nature,2005.433:278.
  • 8Lee DK,Suh D,Edenberg HJ,et al.POZ Domain Transcription Factor,FBI-1,Represses Transcription of ADH5/FDH by Interacting with the Zinc Finger and Interfering with DNA Binding Activity of Sp1[J].J Biol Chem,2002,277(30):26761.
  • 9Davies JM,Hawe N,Kabarowski J,et al.Novel BTB/POZ domain zincfinger protein,LRF,is a potential target of the LAZ-3/BCL-6oncogene[J].Oncogene,1999,18(2):365.
  • 10Maeda T,Hobbs RS,Merghoub T,et al.Role of the protooncogene Pokemon in cellular transformation and ARF repression[J].Nature,2005.433(7023):278.

二级参考文献10

  • 1Sarbia M,Loberg C,Wolter M,et al.Expression of bd2 and amplification of c-myc are frequent in basaloid squarnous cell carcinomas of the esophagus[J].Am J Pathol,1999,155(6):1027～1032.
  • 2Motamed K.SPARC (osteonectin/BM-40)[J].IntJ Biochem Cell Biol,1999,31(12):1363～1366.
  • 3MacDonald TJ,Brown KM,La Fleur B,et al.Expression profiling of medulloblastoma:PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease[J].Nat Genet,2001,29(2):143～152.
  • 4Abeysinghe HR,Cao Q,Xu J,et al.THY1 expression is associated with tumor suppression of human ovarian cancer[J].Cancer Genet Cytogenet,2003,143(2):125～132.
  • 5Michael IK,Alexandra G,Rolf A,et al.Enhanced Expression of SPARC/Osteonectin in the Tumor-associated Stroma of NonSmall Cell Lung Cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients[J].Cancer Res,2003,63(1):5376-5380.
  • 6Yamashita K,Upadhay S,Mimori K,et al.Clinical significance of secreted protein acidic and rich in cystein in esophageal carcinoma and its relation to carcinoma progression[J].Cancer,2003,97(10):2412 ～2419.
  • 7Gooden MD,Vernon RB,BassukJA,et al.Cell cyde-dependent nuclear location of the matricellular protein SPARC:association with the nuclear matrix[J].J Cell Biochem,1999,74(2):152～167.
  • 8Liu Y,Wang HX,Lu N,et al.Translocation of annexin I from cellular membrane to the nuclear membrane in human esophageal aquamous cell carcinoma[J].World J Gastroenterol,2003,9 (6):645～649.
  • 9Gilles C,Bassuk JA,Pulyaeva H,et al.SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines[J].Cancer Res,1998,58(23):5529～5536.
  • 10Croix SB,Rago C,Velculescu V,et al.Genes expressed in human tumor endothelium[J].Science,2000,289(18):1197 ～ 1202.

共引文献11

同被引文献23

  • 1蔡思,于永春.特殊的原癌基因pokemon[J].国际外科学杂志,2006,33(6):464-467. 被引量：12
  • 2计勇,何晓顺,马毅,朱晓峰,张韧,欧志英.Pokemon在肝细胞癌及癌旁、癌以远组织、肝硬化组织及正常肝组织中的表达[J].中华实验外科杂志,2007,24(2):187-189. 被引量：11
  • 3李剑峰,白玉贤.Pokemon基因研究进展[J].实用肿瘤学杂志,2007,21(1):98-100. 被引量：5
  • 4PHAN RT, DALLA FR. The BCL - 6 proto - oncogene suppresses p53 expression in germinal center B cells [ J ]. Nature, 2004,432 (7017) :635 -639.
  • 5MAEDA T, HOBBS RM, MERGHOUB T, et al. Role of the proto- oncogene pokemon in cellular transformation and ARF repression [ J ]. Nature ,2005,433 (7023) :278 - 285.
  • 6MORRISON D J, PENDERGRAST PS, STAVROPOULOS P, et al. FBI, a factor that binds to the HIV - 1 inducer of short transcripts ( IST), is a pozdo - mainprotein [ J ]. Nucleic Acid Res, 1999,5 (27) :1251 - 122.
  • 7DAVIES JM, HAWE N, KABAROWSKI J, et al. Novel BTB/POZ domain zincfinger protein, LRF, is a potential target of the LAZ - 3/BCL - 6 oncogene [ J ]. Oncogene, 1999,18 (2) :365 - 375.
  • 8LEE DK, KANG JE, PARK H J, et al. FBI - 1 enhances transcription of the nuclear factor - KB ( NF - KB ) - responsive E - selectin gene by nuclear local - ization of the p65 subunit of NF - KB[J]. J Biol Chem,2005,280(30) :27783 -27791.
  • 9PIOTROWSKA A, IZYKOWSKA L, PODHORSKA - OKOLOW M, et al. The structure of NF - kappa B family proteins and their role in apoptosis[ J]. Postepy Hig Med Dosw(Online) ,2008,62: 64 - 74.
  • 10BERTWISTLE D, ZINDY F, SHERR CJ, et al. Monoclonal antibodies to the mouse pl9(Arf) tumor suppressor protein [ J]. Hybrid Hybridomics, 2004,23 ( 5 ) : 293 - 300.

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实用癌症杂志
2010年 第4期

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