摘要
目的介绍结直肠癌Lewis-Selectin转移途径和西咪替丁抗癌辅助治疗的研究进展。方法收集近年来国内、外有关Lewis-Selectin转移途径和西咪替丁抗转移辅助治疗研究的文献并作综述。结果在Lewis抗原,唾液酸化LewisX(sLeX)在结直肠癌中表达阳性率最高,肿瘤细胞借助细胞表面sLeX与激活的血管内皮细胞的E-selectin和P-selectin相互作用,从而促使肿瘤侵袭和转移;西咪替丁可提高宿主对肿瘤细胞的免疫反应,影响肿瘤新生血管的生成,具有抑制肿瘤生长和转移的重要作用,且对sLeX阳性的结直肠癌患者的疗效要好于阴性者。结论 Lewis-Selectin转移途径是结直肠癌重要转移途径之一,西咪替丁对sLeX高水平表达的结直肠癌患者有一定的抗转移治疗作用。
Objective To summarize the advancement on Lewis-Selectin metastasis pathway and anti-tumor treatment of cimetidine in colorectal cancer.Methods Domestic and international publications involving Lewis-Selectin metastasis pathway and anti-tumor role of cimetidine in recent years were collected and reviewed.Results The expression of sialyl Lewis X （sLeX） was most significant in Lewis-Selectin metastasis pathway in colorectal cancer.Cancer cells could interact with E-selectin and P-selectin of activated vascular endothelial cells by sLeX ligand on the cell surface,thereby prompting invasion and metastasis.Cimetidine could inhibit the growth of tumor,improve immune response of the host to tumor cell,inhibit angiogenesis of tumor and metastasis.The curative effect of cimetidine on colorectal cancer patients with positive sLeX expression was better than that with negative sLeX expression.Conclusion Lewis-Selectin metastasis pathway is one of the important metastasis pathway in colorectal cancer.Cimetidine can prevent metastasis of colorectal cancer by blocking sLeX expression.
出处
《中国普外基础与临床杂志》
CAS
2010年第7期760-764,共5页
Chinese Journal of Bases and Clinics In General Surgery
