清热活血中药治疗不稳定型心绞痛的临床研究

Clinical Study of Heat-clearing and Blood-activating Chinese Herbal Medicine for Treatment of Unstable Angina

目的观察清热活血中药对不稳定型心绞痛的治疗效果。方法选择50例不稳定型心绞痛的住院患者,随机分为试验组和对照组,两组患者在同时给予标准的现代医学药物治疗的基础上,试验组加用清热活血中药,对照组用活血中药,疗程均为两周。结果与对照组相比,试验组的症状疗效、证候积分疗效及心电图疗效的评定均无显著性差异。治疗后血浆C-反应蛋白、纤维蛋白原及D-二聚体的浓度明显下降(P<0.01),且试验组降幅均大于对照组(P<0.05)。结论在积极的现代医学规范治疗基础上,加用清热活血中药治疗能够有效抑制患者的炎症反应,降低血液黏度,改善血液高凝状态,从而可能起到保护血管内皮,稳定冠状动脉粥样斑块,并抑制局部血栓形成,显示其对不稳定型心绞痛的潜在治疗作用。

Objective To observe the efficacy of heat-clearing and blood-activating Chinese herbal medicine for the treatment of unstable angina（ UA ）. Methods Fifty UA inpatients were randomly divided into two groups： experimental group and control group. All the patients of two groups were given standard western medicine. Additionally, the experimental group were given the decoction of heat-clearing and blood-activating Chinese herbal medicine and the control group were given the decoction of blood-activating Chinese herbal medicine. The treatment last for two weeks. Results The efficacy on symptoms, syndrome scoring and electrocardiogram in the experimental group was similar to that in the control group. But after treatment, the plasma concentrations of C-reactive protein, fibrinogen and D - Dimer were decreased in both groups（P 〈 0.01）, and the decrease was obvious in the experimental group（P 〈 0.05）. Conclusion Based on the active treatment with standard western medicine, heat-clearing and blood-activating Chinese herbal medicine can effectively inhibit the inflammatory reaction, reduce blood viscosity and improve blood hypercoagulabale state, thus to protect blood vessel endothelium, stabilize coronary artery atheromatous plaque and inhibit local thrombosis, which shows potential therapeutic effect for UA.