稀土硝酸铈治疗变应性鼻炎的实验研究

AN experimental study on therapeutic effects of cerium nitrate on allergic rhinitis

目的:研究硝酸铈治疗实验性变应性鼻炎的治疗效果。方法:健康豚鼠39只随机分成正常对照组,变应性鼻炎组:用2,4-二异氰酸甲苯酯(2,4-Toluene-Dissocya-nate,TDI)作致敏原,经鼻腔滴入建立变应性鼻炎模型。治疗期间变应性鼻炎组动物随机分成阳性对照组、药物治疗对照组、硝酸铈治疗组3组,正常对照组设为阴性对照组,治疗15d。观察症状体征、鼻分泌物涂片、鼻粘膜组胺含量和光镜和电镜下鼻粘膜组织形态学的变化。结果:阳性对照组出现鼻痒、喷嚏、流清涕,鼻分泌物嗜酸性粒细胞增多,鼻粘膜组胺含量增多,嗜酸性粒细胞浸润,鼻粘膜细胞超微结构改变。与阳性对照组相比,硝酸铈治疗组上述变化明显减轻。结论:硝酸铈治疗变应性鼻炎有效。

Objective： To study the therapeutic effects of cerium nitrate on experimental allergic rhinitis （AR） in guinea pigs. Methods：39 guinea pigs were divided randomly into two groups： Normal control group and AR group. AR group was induced in guinea pigs with 2,4-Toluene Dissocya nate（ TDI）, intranasal instillation of TDI. During the course of treatment, AR group were randomly divided into 3 group, treating group with cerium nitrate, AR model group, and controlling group treated with dexamethasone and ephedrine, while Normal control group was regarded as controlling. The experi- ment was lasted 15 days. During the experimental period,attention was paid to observe changes in symptoms, nasal secretion,histamine content in nasal mucosa, and morphological features of nasal mucosa under light and electron microscopy. Results ：Typical manifestion of AR was seen in the animals of AR model group,including symptoms such as nasal itching, sneezing, rhinorrhea, significantly increased histamine content and eosinophil number, evident ultrastructural changes in nasal mucosa. However, these changes were significantly inhibited in treating group with cerium nitrate. Conclusion：Cerium nitrate is effective in treating AR.