近年体外抗菌活性评估和耐药监测

Assessment of Antibacterial Activity of Antibiotics and Monitoring of Drug-resistance in Recent Years

目的：评估体外抗菌活性和耐药监测。方法：考察院内１９９４年～１９９８年３月由临床分离之１８４株病原菌的耐药情况和评估１１种抗菌药物的体外抗菌活性。结果：头孢曲松抗大肠杆菌，头孢哌酮、阿米卡星抗铜绿假单胞菌仍持有较好的抗菌活性，耐药率低；而头孢唑啉、头孢曲松抗金葡菌，诺氟沙星抗大肠杆菌的抗菌活性在下降中。结论：应根据试验结果选择抗生素。

OBJECTIVE: Evaluating the antibacterial activity of antibiotics and monitoring drug-resistance METHODS:The drug-resistance was detected on 184 strains of bacteria isolated from clinical specimens during the period 1994～ March,1998 and in vitro antibacterial activities of 11 antibiotics were evaluated. RESULTS: Ceftriaxone and cefoperazo, amikacin ex-hibited high antibacterial activities (low rate of drug resistance)against E. coli and P. aeruginosa , respectively, but the antibac-terial activities of ceftriaxone , cefazolin against S. aureus , and that of norfloxacin against E . coli were decreased. CONCLUSION:Antibiotics should be selected according to the test results.