三氯苯达唑治疗大鼠斯氏狸殖吸虫感染的实验观察

EXPERIMENTAL THERAPY OF PAGUMOGONIMUS SKRJABINI INFECTION IN RATS WITH TRICLABENDAZOLE

目的：观察三氯苯达唑对大鼠斯氏狸殖吸虫感染的治疗效果。方法：从四川威远县和重庆万盛区采集的溪蟹中分离斯氏狸殖吸虫囊蚴，腹腔内注射感染大鼠。感染后１月和２月分别用总剂量为３００ｍｇ／ｋｇ，２ｄ分服，４５０ｍｇ／ｋｇ，３ｄ分服和６００ｍｇ／ｋｇ，３ｄ分服的三氯苯达唑治疗。结果：治后１月解剖，活虫减少率依次为５０％、８０％和８７％，并在肌肉、肝脏、腹腔、胸腔和肺部均发现虫体明著缩小（约１．５ｍｍ）呈灰白色的死虫。对照组大鼠肺部可见较大的黑色虫囊，内含活的成虫及虫卵。治疗组大鼠肺部虫囊大多数萎缩，成为出血及坏死性病灶。结论：三氯苯达唑对斯氏狸殖吸虫有良好的杀虫作用。

AIM: To observe the therapeutic effect of triclabendazole in rats infected with Pagumogonimus skrjabini . METHODS:Metacercariae of P. skrjabini were isolated from crabs( Sinopotamon )collected from two endemic areas(Weiyuan County of Sichuan Province and Wansheng District of Chongqing Municipality).Wistar rats were each infected intraperitoneally with metacercariae .One month and two months after infection,the infected rats were treated with triclabendazole at the total dosage of 300 mg/kg over 2 days , 450 mg/kg over 3 days and 600 mg/kg over 3 days, respectively. RESULTS:The worm reduction rates were 50%, 80% and 87% respectively one month after completion of treatment. Dead worms (about 1 mm size) recovered from the muscles,liver,abdominal cavity ,chest cavity and lungs were signicantly diminished in size and weight in comparison with those of the control group . Many large (about 1 cm )black colored distended worm cysts usually with two adult worms and many eggs were found in the lungs of the control rats. Most worm cysts in the treated groups of rats were found to be atrophied, changing into hemorrhagic necrotic patches.CONCLUSION:Triclabendazole is highly active against P. skrjabini in rats.