人参皂苷M1硬脂酸酯抗肿瘤活性的研究

Study on the antitumor activities of ginsenoside M1 Stearate

研究人参皂苷M1硬脂酸酯(SM1)对小鼠肝癌腹水型(HepA)细胞和小鼠胃癌(MFC)细胞的生长抑制作用。采用动物移植瘤模型,以生理盐水组、阳性药环磷酰胺组作对照,对SM1抗癌活性进行筛选评价。对于小鼠肝癌(HepA)细胞,SM1给药组瘤重为1.44±0.57克,其肿瘤抑制率为51.66%,与生理盐水处理的对照组瘤重(2.97±0.54克)比较差异具有极显著统计学意义(P<0.001);对于小鼠胃癌(MFC)细胞,SM1给药组瘤重为1.60±0.68克,其肿瘤抑制率为52%,与生理盐水处理的对照组瘤重(3.32±1.39克)比较差异具有显著统计学意义(P<0.05)。SM1能显著抑制小鼠体内肝癌细胞和胃癌细胞的生长,具有显著的抗肿瘤作用。

Objective： to observe the inhibitory effects of ginsenoside M1 Stearate（SM1 ） on growth of HepA and MFC cells in mice. Methods： Applied animal neoplasia model to mice experiment. After the subcutancous trans- plantation of HepA and MFC cells, respectively, in the oxter of nude mice, the mice were randomly divided into control group, Cyclophosphamide group and SM1 group. The inhibition rate of tumor was measured after 10 days. Results ： The tumor weight was decreased（ 1.44 ± 0.57g） and The inhibition rate of tumor was in- creased（ 51.66% ）in SM1 group vs control group（P 〈 0. 001 ）in transplantation of HepA mice. In trans- plantation of MFC mice, The tumor weight was decreased（ 1. 605 ± 0.68g） and The inhibition rate of tumor was increased（52% ）in SM1 group vs control group （P 〈 0.05）. Conclusion： SM1 might have antitumor activities by significantly inhibiting the growth of HepA and MFC tumor in mice.