褪黑素能类药物治疗睡眠障碍的研究进展

Advance in research on treatment of sleep disorders with melatonergic drugs

睡眠障碍治疗困难,需要开发新的、更好的睡眠治疗药。褪黑素是松果体分泌的一种神经内分泌激素,能通过特异受体介导,发挥调节昼夜节律和睡眠的作用。研发褪黑素能类药物(包括褪黑素、褪黑素类似物/替代品、受体激动剂)治疗睡眠障碍具有重要意义,本文综述了褪黑素以及雷美尔通、特斯美尔通、阿戈美拉汀等褪黑素受体激动剂治疗睡眠障碍的研究进展。

Sleep disorders is refractory to most medications.There is demands for the development of more effective,better tolerance and newer hypnotic drugs.Melatonin is a hormone synthesized principally in the pineal gland.It is centrally involved in maintaining circadian rhythmicity and regulating sleep,mediated by melatonin receptors.It is of important significance to develop melatonergic drugs and melatonin receptor agonists as drugs for treating sleep disorders.In this review,melatonin,melatonin receptor agonists,such as ramelteon,tasimelteon and agomelatine,which are currently being researched in treating sleep disorders are reviewed.