363例不良妊娠病人支原体感染及药物敏感性分析

Analysis of the Mycoplasma infection and drug sensitivity test in 363 patients with abnormal pregnancy

目的:回顾性分析363例不良妊娠病人生殖道支原体感染及药物敏感性状况,为指导医生合理用药提供参考。方法:随机选择2008年1月-2010年1月在深圳市宝安区妇幼保健院就诊的不孕症、习惯性流产、死胎病人共计363份病历作为观察组,按年龄、职业、文化程度及营养状况匹配363例正常孕产妇病历作为对照组,所有研究对象用微生物检验法作支原体培养及药物敏感试验。结果:观察组支原体、解脲脲支原体(Ureaplasma urealyticum,Uu)、Uu+人支原体(mycoplasma hominis,Mh)和Mh检出率分别为65.01%、57.58%、4.96%和2.48%,其中Uu、Uu+Mh及Mh检出率均显著高于对照组。观察组各类病人支原体检出率无显著性差异,但均显著高于对照组。Uu、Mh对交沙霉素、克拉霉素和多西环素具有较高的敏感性;Uu+Mh对抗生素的敏感率前3位依次是交沙霉素、多西环素和阿奇霉素。结论:生殖道支原体感染可能与不孕症、习惯性流产及死胎等有关;支原体药物敏感试验有助于合理用药。

Objective：To analyze retrospectively the Mycoplasma infection and drug sensitivity test in 363 patients with abnormal pregnancy and to offer reference for rational drug use of physicians.Methods：Three hundred and sixty-three patients with abnormal pregnancy including sterility,habitual abortion and dead embryo were sampled into the observation group from January 2008 to January 2010 in the Bao’an Maternity and Children Healthcare Hospital.Meanwhile,363 cases of normal pregnant women were pair matched into control group according to age,occupation,cultural degree and nourishment conditions.Mycoplasma culture and drug sensitivity test were done in the 726 cases.Results：The infection rates of Mycoplasma,Ureaplasma urealyticum（Uu）,Uu＋Mycoplasma hominis （Uu＋Mh） and Mh were 65.01%,57.58%,4.96% and 2.48% respectively in the observation group,which showed significant differences compared with control group.The infection rates of Mycoplasma in patients of different categories of observation group did not show significant differences,but showed significantly higher level than those in control group.Uu and Mh were sensitive to josamycin,clarithromycin and doxycycline.The top three sensitive drugs to Uu＋Mh were josamycin,doxycycline and azithromycin.Conclusion：Mycoplasma infection of reproductive tract may cause sterility,habitual abortion and dead embryo.The drug sensitivity test of Mycoplasma is helpful to rational use of medicine.