干燥综合征腮腺^(99)Tc^mO_4-核素动态显像与唇腺活检的对比研究

The comparative study between salivary gland ^(99)Tc^mO_4-nuclide dynamic imaging and labial biopsy in sjogren's syndrome

目的:与唇腺活检相对比,评价核素动态显像在诊断干燥综合征(SS)中的作用和价值。方法:对143例干燥综合征患者和22例正常人分别进行核素动态显像,所有病例均经唇腺活检病理证实。结果:正常对照组99TcmO4-摄取率为5.12±3.17,最大浓聚时间为(22.5±3.01)min,排泄率为(52.4±5.62)%;SS组患者99TcmO4-摄取率为2.02±1.02,最大浓聚时间(17.8±4.53)min,排泄率为(10.6±6.04)%,两组差异有统计学意义(P<0.05)。与唇腺活检结果对比,核素动态显像的灵敏度为94.4%,特异性为95.5%。结论:对于临床怀疑为SS的患者,99TcmO4-唾液腺显像是一种值得推广应用的首选筛查方法。

Objective：Compared with labial gland＇s biopsy,the nuclide dynamic imaging was evaluated in effectiveness and value to diagnose the Sjogren＇s syndrome.Methods：Nuclide dynamic imaging were conducted on 143 cases with Sjogren syndrome and on 22 normal subjects without the disease.Labial gland＇s biopsy was done to the cases suffering from Sjogren syndrome.Results：The group of normal control 99 TcmO4-uptake rate was 5.12±3.17,the max time of concentration was（22.5±3.01） min,the rate of excrete was（52.4±5.62） %;In the SS group,99 TcmO4-uptake rate was 2.02±1.02,the max time of concentration was（17.8±4.53） min,the rate of excrete was（10.6±6.04） %;Two groups were significant difference statistically（P0.05）.Compared with labial gland＇s biopsy,the sensitivity and the specificity of the nuclide dynamic imaging were 94.4%,95.5% respectively.Conclusion：For patient suspected with the SS in clinic,the nuclide dynamic imaging of salivary gland is the first choice for scanning and is worth promoting the application.