伊班膦酸钠治疗恶性肿瘤骨转移的临床观察

The clinical observe of ibandronate treated in malignant cancer bone metastasis

目的临床分析伊班膦酸钠治疗恶性肿瘤骨转移的疗效,并与帕米膦酸二钠比较。方法将84例恶性肿瘤骨转移患者随机分为伊班磷酸钠组44例和帕米膦酸二钠组40例。分别给予伊班膦酸钠6mg、帕米膦酸二钠30mg静脉滴注,每4周1次,2周期后评价疗效。结果伊班膦酸钠组和帕米膦酸二钠组骨转移癌痛有效率为81.8%和67.5%,血钙水平为(2.10±0.15)mmol/L和(2.64±0.16)mmol/L,2组差异均有统计学意义(P<0.05)。2组在生活质量改善方面差异无统计学意义(P>0.05)。且无明显不良反应。结论伊班膦酸钠在治疗恶性肿瘤骨转移中镇痛及降低血钙水平上优于帕米膦酸二钠,值得临床推广应用。

Objective To analysis the effect of ibandronate treatment of malignant cancer bone metastasis,and compared with pamidronate.Methods 84 cases patients of malignant bone metastases were randomly divided into ibandronate group（44 cases）and pamidronate disodium group（40 cases）.Two group each other were gave ibandronate 6mg,pamidronate disodium 30mg,mintravenous,once every four weeks.After two cycles,the effect were evaluated.Results Cancer pain of bone metastasis rate of two groups were 81.8% and 67.5%,the level of calcium were（2.10±0.15）mmol/L and（2.64±0.16）mmol/L,the difference between the two groups were statistically significant（P0.05）.To improve the quality aspect in two groups was significant statistics（P0.05）.And there was no visible reaction.Conclusion Ibandronate in the treatment of cancer pain of bone metastasis and reduced the role of calcium levels was better than pamidronate disodium.