丹红注射液对急性脑梗死患者血液流变学的影响

Effects of Danhong injection on the hemorheology in patients with acute cerebral infarction

目的观察丹红注射液对脑梗死患者血液流变学和纤维蛋白原含量的影响。方法将84例急性脑梗死患者随机分为两组,丹红组给予丹红注射液30 ml加入0.9%氯化钠注射液250 ml中,每日一次静脉滴注;丹参组给予丹参注射液30 ml加入0.9%氯化钠注射液250 ml中,每日一次静脉滴注。疗程14 d。于治疗前后根据神经功能缺损程度(NDS)评分标准进行评分,并检测血液流变学及纤维蛋白原含量。结果丹红组的总有效率(82.5%)显著高于丹参组(72.8%)(P<0.05);丹红组治疗后全血黏度、血浆黏度、红细胞聚集指数、纤维蛋白原较治疗前显著改善(P<0.05,或P<0.01);丹参组治疗后仅全血黏度显著改善(P<0.05);两组治疗后比较,丹红组全血黏度(中切)、血浆黏度、纤维蛋白原显著低于丹参组(均P<0.05)。结论丹红注射液可能通过改善血液流变学、降低纤维蛋白原含量起到治疗作用。

Objective To observe the therapeutic effect of Danhong injection in the treatment of acute cerebral infarction and its influence on hemorheology and fibrinogen level. Methods 84 patients with acute cerebral infarction were randomly divided into two groups. 40 patients in Danhong Injection group were treated with Danhong Injection（30ml plus 250ml physiological saline, intravenously guttae ,qd ） ;44 patients in Salvia Mihiorrhiza Injection group were treated with Salvia Miltiorrhiza（ 30ml plus 250ml physiological saline, intravenously guttae, qd）. All treatment lasted 14 days. NDS was introduced to evaluate the clinical efficiency. The indexes of hemorheology and fibrinogen level in two groups was sampled before and after treatment. Results Total effctive rate in Danhong group （82.5 % ） was signifcantly higher than that in Salvia Mihiorrhiza group（72.8% ）（P 〈 0.05 ）;Compared with those before treatment, the indexes of hemorheology and fibrinogen content in Danhong group decreased significantly （ P 〈 0.05, or P 〈 0.01 ） ;However, only indexes of whole blood viscosity （ low and high shear rate） in Salvia Miltiorrhiza group decreased significantly after treatment（ P 〈 0.05 ）. After treatment, indexes of whole blood viscosity（ moderate shear rate）, plasma viscosity and fibrinogen content in Danhong group was significantly lower than that in Salvia Mihiorrhiza group （ all P 〈 0.05 ）. Conclusion Danhong Injection may have neuroprotective effcts on acute cerebral infarction by improving the indexes of hemorheology and decreasing fbrinogen content,which was better than the effect of Salvia Mihiorrhiza Injection.