乳腺原发性血管肉瘤临床病理分析

Clinical Pathological characteristics of Primary Angiosarcoma of Breast

目的探讨乳腺原发性血管肉瘤的临床病理特点和鉴别诊断。方法对1例原发性血管肉瘤进行组织形态学和免疫组化分析，并文献复习。结果乳腺血管肉瘤主要发生于绝经前妇女，临床表现不典型，组织学显示肿瘤由弥漫增生的异常血管组成，但不同分化程度组织学变化大，肿瘤通常表达CD31和CD34，目前主要采用手术治疗。结论乳腺原发性血管肉瘤较少见，肿瘤分化程度与预后密切相关。

Objective To Study the characteristics and differential diagnosis of angiosarcoma in breast. Methods One ease of primary angiosareoma of breast was reported with review of the literature.Histological appearances and immunohistochemistry were analyzed. Results Primary angiosarcoma of breast usually affected premenopausal women. Clinical manifestation was not typical, Tumor constitute suffused abnormal hyperplasia vessel, and the histological features varied greatly.The tumor cells expressed CD31 and CD34 .At present total mastectomy was the recommended primary surgical therapy. Conclusion Primary angiosarcoma of breast is a rare neoplasm, The histological grading of the tumor correlates closely with the prognosis.