原发性免疫缺陷病和疫苗衍生脊髓灰质炎病毒的研究进展

Review of the Studies on Primary Immunodeficiency Disorder and Vaccine-derived Poliovirus

随着全球消灭脊髓灰质炎(脊灰)活动进入到最后阶段,世界各地陆续发现了多例免疫缺陷病患者排出的疫苗衍生脊灰病毒(Vaccine-derived Poliovirus,VDPV)。由于此类病例能够长期携带并向环境中排出VDPV,各国开始关注免疫缺陷病患者排出PV的问题,并对消灭脊灰后的免疫策略重新进行思考。

On the last stage of Global Polio Eradication Initiative（GPEI）,a number of cases with Primary Immunodeficiency（PID） disorder were detected excreting the Vaccine-derived Poliovirus（VDPV）.Due to these cases can be prolonged or chronic excretion of the VDPV in the environment,all countries have to gradually focus on these cases and reconsidering the national strategies of polio vaccine in the post-eradication era themselves.