薄层色谱法监测罗沙替丁醋酸酯的合成

Monitoring the Synthesis of Roxatidine Acetate by TLC

用薄层色谱法监测罗沙替丁醋酸酯的最后一步合成过程,选择石油醚∶氯仿∶丙酮∶乙醇(23∶12∶2∶3,V/V/V/V)为展开剂跟踪检测罗沙替丁醋酸酯合成过程中的产物时,目标产物与杂质以及反应产物能够在薄板上很好地分离。

The last synthesis process of roxatidine acetate was monitored by TLC.The experiments showed that when choose petroleum ether：chloroform：acetone：ethanol（23：12：2：3;V/V/V/V） as developer,the objects can be well separated on silica gel plate.