期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

百草枯中毒大鼠肺组织环氧化酶-2和微血管密度的表达 被引量：2

原文传递
导出
摘要 百草枯中毒的特点是多器官功能损伤。肺是百草枯中毒主要的靶器官。百草枯中毒在早期常引起肺水肿、肺出血等为特征的肺损伤，在后期可进行性地发展为不可逆性肺间质纤维化。目前百草枯引起肺损伤的机制尚不清楚。还氧化酶2（COX-2）参与炎症和血管增生的病理过程，在哮喘、肺损伤、肺癌、肺纤维化中发挥重要作用。本研究探讨COX-2在百草枯中毒肺损伤中的作用及可能机制。
作者 李俊英 何庆 董芸
机构地区 四川省人民医院急救中心EICU 四川大学华西医院急诊科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2010年第7期708-709,共2页 Chinese Journal of Emergency Medicine
关键词 百草枯中毒 大鼠肺组织 环氧化酶-2 微血管密度 多器官功能损伤 肺间质纤维化 COX-2 肺损伤
分类号 R595.4 [医药卫生—内科学]
  • 相关文献

参考文献9

  • 1王永进,王泽惠.百草枯中毒治疗的研究进展[J].中国急救医学,2003,23(6):404-406. 被引量：156
  • 2Chen P.Cai Y,Yang ZG.et al.Involvement of PKC,p38 MAPK and AP-2 in IL-1 beta-induced expression of cyclooxygenase-2 in human pulmonary epithelial cells[J].Respirology,2006,ll(l):18-23.
  • 3Neuhofer W.Holzapfel K,Fraek ML.et al.Chronic COX-2 inhibition reduces medullary HSF70 expression and induces papillary apoptosis in dehydrated rats[J].Kidney Intemational,2004,65(2)i431-441.
  • 4Park SW,Sung MW,Heo DS,et al.Nitric oxide upregulates the cyclooxygenase-2 expression through the cAMP-response element in its promoter in several cancer cell lines[J].Oncogene,2005,24:6689-6698.
  • 5Chiang YM,Lo CP.Chen YP.et al.Ethyl caffeate suppresses NF-kap-paB activation and its downtream inflammatory mediators,iNOS,COX-2,and PCE2 in vitro or in mouse skin[J].British Journal of Pharmacology,2005,146(3):352-363.
  • 6Buccoliero AM,Caldarella A,Chen CF.et al.Inducible cycloo-xygenase (COX-2) inglioblastoma-clinical and immunohistochemical (COX-2-VEGF) correlations[J].Clinical Neuropathology,2006,25(2):59-66.
  • 7sujii M,Kawano S.Tsuji S.et al.Cyclooxygenase regulates angiogenesis induced by colon cancer cells[J].Cell,1998,93(5):705-716.
  • 8Keane MP,Donnelly SC.Bleperio JA.et al.Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angio-genic activity and procollagen levels in acute respiratory distress syn-drome[J].Journal of Immunology,2002,169(11):6515-6521.
  • 9Sanchez-Alcazar JA,Bradbury DA,Pang L,et al.Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways[J].Lung Cancer,2003,40(l):33-44.

二级参考文献21

  • 1Ito S, Kudo K,Imamura T, et al. Detection of drugs and poisons in postmortem tissues - determination of paraquat in tissues of rabbits buried underground[J]. Nippon Hoigaku Zasshi, 1997,51(2) :83 - 88.
  • 2Smith LL, Lewis CP, Wyatt I,et al.The importance of epithelial uptake systems in lung toxicity[ J ]. Environ Health Perspect, 1990,85: 25 - 30.
  • 3Costantini P, Petronilli V,Colonna R,et al. On the effect of paraquat on isolated mitochondria.Evidence that paraquat causes opening of the cyclosporin A- sensitive permeability transition pore synergistically with nitric oxide[ J ]. Toxicology, 1995,99: 77 - 88.
  • 4Kojima S, Miyazaky, Y, Honda T, et d.Protective effects of dextran Sulfate and polyvinyl sulfate against acute toxicity of paraquat in mice [ J ].Toxicology, 1991,69( 1 ) :93 - 99.
  • 5Yang TS,Chang YL, Yen CK.Haemoperfusion treatment in pigs experimentally intoxicated by paraquat [ J ] .Hum Exp Toxicol, 1997, 16(12) :709-715.
  • 6Hampson EC, Pond SM. Failure of haemoperfusion and haemodialysis to prevent death in paraquat poisoning. A retrospective review of 42 patients[J].Med Toxicol Adverse Drug Exp, 1988,3(1):64-71.
  • 7Venkatesan N.Pulmonary protective effects of curcumin against paraquat toxicity[J]. Life Sci ,2000,66(2) : PL 21 - 28.
  • 8Lin JL, Leu ML, Liu YC, et al. A prospective clinical trial of pulse therapy with glucocotticoid and cyclophosphamide in moderate to severe paraquat- poisoned patients[ J ]. Am J Respir Crit Care Med, 1999,159 ( 2 ) : 357 -360.
  • 9Vanderwal NA, Vanoirschot TF, Van DijK A, et al.Mechanism of protection of alveolar type Ⅱ cells against paraquat- induced cytotoxicity by doferoxamine [ J ] . Biochem Pharmacol, 1990, 39 ( 11 ) :1665 - 1671.
  • 10Chen N, Bowles MR, Pond SM.Prevendon of paraquat toxicity in suspensions of alveolar type Ⅱ cells by paraquat - specific antibodies[J].Hum Exp Toxicol,1994,13(8):551-557

共引文献155

同被引文献6

引证文献2

二级引证文献2

中华急诊医学杂志
2010年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部