摘要
共刺激分子B7-CD28家族在免疫应答过程中起着重要的调节作用，其中CD28／细胞毒性T淋巴细胞相关抗原4与B7、可诱导共刺激分子和程序性死亡-1因子及其配体在心肌组织中的表达变化与自身免疫所引起的心肌炎症反应密切相关，选择性阻断T细胞活化的共刺激信号通路可控制疾病的发展，对心肌炎的治疗具有重要意义。
Co - stimulatory molecule B7 - CD28 family plays a pivotal role in regulating specific immune response. The expression of CD28, CTLA -4, ICOS, PD - 1 and their ligands in myocardium is closely related to the myocardial inflammation caused by autoimmunity. Blockade of co - stimulatory pathway of T cell activation is effective against myocarditis and plays an important role in the treatment of myocarditis.
出处
《国际老年医学杂志》
2010年第4期161-165,共5页
International Journal of Geriatrics
