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胸苷磷酸化酶与恶性肿瘤

Thymidine Phosphorylase and Malignancy
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摘要 恶性肿瘤的发生和发展是一个极其复杂的过程。新生血管的形成在肿瘤的发生、发展和转移的过程中起着重要作用。胸苷磷酸化酶是新近发现的一个血管生长因子，其在恶性肿瘤组织中的表达与肿瘤的发生、发展、预后及肿瘤的化疗有密切的关系。本文就这方面的研究进展做一综述。 The occurrence and development of malignant tumor are a extremely complex process. The formation of new blood vessels plays an important role in the occurrence, development and metastasis process of tumor. Thymidine phosphorylase （TP） is a newly discovered vascular growth factor. The expression of TP in malignant tumor tissue has a close relationship with the occurrence, development, prognosis and chemotherapy of malignant tumor.
作者 程乐平 王莹
机构地区 皖南医学院弋矶山医院呼吸内科
出处 《国际老年医学杂志》 2010年第4期185-190,共6页 International Journal of Geriatrics
关键词 胸苷磷酸化酶 恶性肿瘤 发生 发展 Tbymidine phosphorylase Malignancy Occurrence Development Progress
分类号 R730.2 [医药卫生—肿瘤]
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参考文献28

  • 1Sumizawa T, Furukawa T, Haraguehi M, et al. Thymidine phosphorylase activity associated with platelet - derived endothelial cell growth factor [ J]. J Biochem (Tokyo), 1993, 114 (1): 9-14.
  • 2Toi M, Atiqur Rahman M, Bando H, et al. Thymidine phosphorylase ( platelet - derived endothelial - cell growth factor) in cancer biology and treatment [ J ]. Lancet Oncol, 2005, 6 (3): 158-166.
  • 3Tsujitani S, Saito H, Maeta Y, et al. Neoangiogenesis in patients with gastric carcinoma in relation to the expression of vascular endothelial growth factor and thymidine phosphorylase [J]. Anticancer Res, 2004, 24 (3b): 1853-1859.
  • 4Yasuno M, Mori T, Koike M, et al. hnportance of thymidine phosphorylase expression ira tumor stroma as a prognostic factor in patients with advanced colorcctal carcinoma [J]. Oncol Rcp, 2005, 13 (3): 405-412.
  • 5Brown NS, Jones A, Fujiyanm C, et al. Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenie factors [ J ].Cancer Res, 2000, 60 (22): 6298-6302.
  • 6Miyadera K, Sumizawa T, Haraguchi M, et al. Role of thymidine phosphorylasc activity in the angiogcnic effect of platelet - derived endothelial cell growth factor/thymidine phosphorylase [J]. Cancer Res, 1995, 55 (8): 1687-1690.
  • 7Konno S, Takebayashi Y, Aiba M, et al. Clinicopathological and prognostic significa - nee of thymidine phosphorylase and proliferating cell nuclear antigen in gas-tric careinoma [J]. Cancer Lett, 2001, 166 (1), 103-111.
  • 8Matsuura T, Kuratate I, Teramachi K, et al. Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorcctal carcinomas [J]. Cancer Res, 1999, 59 (19): 5037-5040.
  • 9Hata K, Fujiwaki R, Maede Y, et al. Expression of thymidine phosphorylase in epithelial ovarian cancer: correlation with angiogenesis, apoptosis, and ultrasound- derived peak systolic velocity [ J ]. Gynecol Oncol, 2000, 77 (1): 26-34.
  • 10Nozawa T, Enomoto T, Koshida Y, et al. Specific enhanced expression of platelet - derived endothelial eell growth factor in submucosa of human colorectal cancer [J]. Dis Colon Rectum, 2004, 47 (12): 2093 - 2100.

二级参考文献25

  • 1吕志强,李海刚,谢德荣,张惠忠,沈溪明,曾韵洁,曾弘.非小细胞肺癌组织中VEGF-C和VEGFR-3的表达及其临床意义[J].癌症,2005,24(9):1132-1135. 被引量：22
  • 2Toim, Atiqur RM, Bando H, et al. Thymidine phosphorylase ( platelet derived endothelial cell growth factor) in cancer biology and treatment [ J ]. Lancet Onco1,2005,6 ( 3 ) : 158 - 166.
  • 3Hall FT, Freeman JL, Asa SL, et al. Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma[ J]. Arch Otolaryngol Head Neck Sury,2003,129 (7) :716 - 719.
  • 4Takanami I. Lymphatic microverssel density using D2-40 is associated with node metastasis in non-small cell lung cancer [ J ]. Oncol Rep, 2006, (512) :437 -442.
  • 5Kaiserling E. Immmunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology [ J ]. Pathology, 2004,25 ( 5 ) : 362 - 374.
  • 6Su JL, Shih JY, Yen ML, et al. Cyclooxygenase-2 induces EPl-and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation:A novel mechanism of lymphangiogenesis in lung adenocarcinoma[ Jl. Cancer Res,2004,64(2) :554 -564.
  • 7Liakakors T,Troupis T,Ghiconti I, et al. Immunohistochemical localization of thymidine phosphorylase in gastric cancer:Is therea role of the differential expression in tumor cells and associated stromal cell? [ J ]. Anticancer Res,2006,26 ( 5 B ) :3899 - 3903.
  • 8Takayama T, Mugiya S, Sugiyama T, et al. High levels of thymidine phosphorylase as an independent prognostic factor in renal cell carci-noma[ J]. Jpn J Clin 0ncol,2006,36(9) :564 -569.
  • 9Yamashita J, Ogawa M, Abe M, et al. Platelet-derived endothelial cell growth factor/thymidine phosphorylase concentrations differ in small cell and non-small cell lung cancer [ J]. Chest, 1999, 116 ( 1 ) : 206 -211.
  • 10Liang P, Nakada I, Hong JW, et al. Prognostic significance of im- munohistochemically detected blood and lymphatic vessel invasion in colorectal carcinoma: Its impact on prognosis[ J]. Ann Surg Oncol, 2007,14 (2) :470 - 477.

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国际老年医学杂志
2010年 第4期

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