干扰素治疗慢性乙型肝炎43例

Clinical study on treatment of chronic hepatitis B in children with α-2b interferon

探讨干扰素治疗小儿慢性乙型肝炎（CHB）的疗效、安全性及其影响因素。方法用干扰素α－2b治疗43例小儿CHB患者，并以32例患儿做为对照。结果治疗组病毒复制标志的阴转率显著高于对照组；ALT复常率近期显著高子对照组，远期则无明显差别。治疗前ALT高值、血清HBV－DNA低水平及非母婴传播为干扰素治疗的有利因素。干扰素治疗组未见严重不良反应。结论干扰素可用于小儿CHB的治疗，疗效的高低取决于适当病例的选择。

To evaluate the efficacy and safety of interferon-α(IFN-α) therapy and analyse the factors affecting response to this therapy in children with chronic viral hepatitis B(CHB).Methods: 75 children(2. 5 to 15 years) with CHB. HBV-DNA and eAg serum positivity. were divided randomly into two groups:IFN-α-treated group (n = 43) were treated with im interferon-alpha 2b 3 million three times per week for 24 weeks followed by another 24 weeks post-treatment observation; Control group (n = 32 ) were treated with the ordinary liver protective medicine.Results: To the short term efficacy of IFN-α treatment. ALT norma lization rate and clearance rate of HBV replication marker was significantly higher in IFN-treated group than that in control group.To the long term efficacy, no significant difference in ALT norma lization rate between two groups was found. The efficacy of IFN treatment was associated with pretreatment ALT level. baseline serum HBV-DNA concentration and serum HBsAg of patient's mother. No severe adverse effects were observed in the IFN-treated groups.Conclusion: IFN-α therapy can be used to treat CHB.the efficacy of which depends on the proper choice of the cases.