神经母细胞瘤的凋亡研究

Study on the apoptosis of neuroblastoma

研究临床神经母细胞瘤凋亡情况，了解其与预后的关系。方法取神经母细胞瘤石腊切片，运用原位DNA末端标记法，检测凋亡细胞，计算凋亡细胞占肿瘤细胞百分比，求得凋亡指数。结果预后好的神经母细胞瘤大于预后差的神经母细胞瘤的凋亡指数。若凋亡指数大于9％，提示自发性消退。结论凋亡指数对神经母细胞瘤判断预后、指导治疗有重要价值。

To work out the expression of apoptosis and the relationship of prognosis in neuroblastoma.Methods: Apoptosis was determined by the Tunel in Neuroblatoma in tissue sections. The apoptotic indexes were the percentages of apoptotic cells among tumor cells.Results: The Apoptotic indexes were higher in the faverable than unfaverable P<0. 01 if the apoptotic index was more than 9% it indicted spontaneous regression.Conclusions: The apoptotic index can be considered as ava luable index to judge progrosis and guide treatment.