肝硬化背景对肝细胞癌超声造影灌注曲线的影响

Effect of cirrhosic liver on dynamic vascular curves analysis of hepatocellular carcinomas at contrast-enhanced ultrasound

目的 对肝细胞癌（hepatocellular carcinoma,HCC）进行超声造影灌注曲线,f（t）分析,探讨肝硬化背景对灌注参数的影响.方法 使用Sonoliver软件对115例HCC患者的超声造影动态图像进行脱机分析,其中有肝硬化背景86例,无肝硬化背景29例,获得分析区和参考区的,f（t）,对,f（t）参数：峰值强度（maximum of intensity,IMAX）、上升时间（rise time,RT）、达峰时间（time to peak,TTP）、平均渡越时间（mean trasit time,mTT）和始消时间（washout time,WT）进行统计学分析.结果 肝硬化组HCC分析区的IMAX为（124.25±5.56）%,RT为（12.98±0.48）s,TTP为（13.70±0.52）s,mTT为（138.61±9.20）s,RS为10.11±0.60,WT为（34.17±2.91）s.非肝硬化组HCC分析区的上述参数分别为（113.65±5.58）%,（13.68 ±0.92）s,（14.39 ±0.94）s,（149.49±21.70）s,8.89±0.77,（28.36±3.25）s.两组HCC的分析区和参考区灌注参数的差异均无统计学意义（P〉0.05）.结论 HCC的灌注参数可评估肿瘤内的血流灌注,肝硬化背景不影响HCC的,f（t）灌注参数.

Objective To study the effect of cirrhosic liver on dynamic vascular curves analysis f（t）of hepatocellular carcinomas（HCCs） at contrast-enhanced ultrasound by exploring the difference between perfusion parameters of HCCs in cirrhotic liver and that in noncirrhotic liver. Methods One hundred and fifteen HCCs were analyzed off-line with dynamic vascular curve f（t） of Sonoliver. The HCCs were divided into 2 groups based on their background liver as cirrhotic liver group （ n = 86） and noncirrhotic liver group （ n =29）. Such parameters as maximum of intensity（IMAX） ,rise time （RT,from 10% to 90% of IMAX）,time to peak（TTP） ,mean trasit time（mTT） ,rise slope（RS） and washout time（WT） of the two groups were analyzed by statistics. Results There was no significant difference in the f（t） parameters of HCCs between cirrhotic liver group and noncirrhotic group（P 〉0. 05） [IMAX：（124. 25 ± 5. 56）% vs （113. 65 ± 5. 58）% ; RT： （12. 98 ± 0. 48）s vs （13. 68 ± 0. 92）s;TTP：（13. 70 ± 0. 52）s vs （14. 39 ± 0. 9）s;mTTi（138. 61 ± 9. 20）s vs （149. 49 ± 21. 70）s;RS：10. 11 ± 0. 60 vs 8. 89 ± 0. 77, WT： （34.17 ± 2. 91 ）s vs （28. 36 ± 3. 25）s]. There was also no significant statistical difference in all above parameters in reference regions for the two group （P 〉 0. 05）. Conclusions The f（t） parameters in HCCs can evaluate blood perfusion of the tumors, and cirrhotic liver does not affect the perfusion parameters of HCCs.